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Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression

التفاصيل البيبلوغرافية
العنوان: Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression
المؤلفون: Jar-Chi Lee, Matthew Karafa, Richard A. Rudick, Sarah E. M. Born, Clara M. Pelfrey, Ioana R. Moldovan, Anne C. Cotleur
المصدر: Journal of neuroimmunology. 141(1-2)
سنة النشر: 2003
مصطلحات موضوعية: Adult, Male, Proteolipid protein 1, Adolescent, T-Lymphocytes, Immunology, chemical and pharmacologic phenomena, Biology, Lymphocyte Activation, Myelin, Disability Evaluation, Interferon-gamma, Multiple Sclerosis, Relapsing-Remitting, medicine, Immunology and Allergy, Humans, Interferon gamma, Myelin Proteolipid Protein, Cells, Cultured, ELISPOT, Multiple sclerosis, Myelin Basic Protein, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Peptide Fragments, Myelin proteolipid protein, Myelin basic protein, Interleukin-10, Up-Regulation, medicine.anatomical_structure, Cross-Sectional Studies, Neurology, Multiple sclerosis functional composite, Chronic Disease, biology.protein, Disease Progression, Cytokines, Female, Neurology (clinical), medicine.drug
الوصف: The relationship between autoreactivity to myelin antigens and disease progression in multiple sclerosis (MS) is not fully understood. We addressed this relationship by cross-sectionally comparing an objective measure of MS disability with immune cytokine responses to myelin proteins. The ELISPOT assay was used to determine the ex vivo interferon gamma (IFNgamma) and interleukin-10 (IL-10) production by peripheral blood mononuclear cells (PBMCs) in response to peptides spanning the entire proteolipid protein (PLP) and myelin basic protein (MBP) molecules in 20 patients with relapsing-remitting (RR) MS and 27 age- and sex-matched healthy controls. MS patients showed significantly higher MBP-induced IFNgamma responses and PLP-induced IL-10 responses compared with healthy controls. Using the Multiple Sclerosis Functional Composite (MSFC), a new multifactorial measure of disability, MS patients showed a significant correlation between the IFNgamma response to PLP peptides and MBP peptides, and disability. In contrast, in MS patients, there was no correlation between the MSFC and the response to unrelated control antigens or mitogens. These data show that myelin-specific T lymphocytes secreting the inflammatory cytokine IFNgamma correlate with functional impairment in MS, supporting an antigen-specific link between the immune response to myelin and disability in MS.
تدمد: 0165-5728
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935ad94550751cb4511d3c89a1eaa81f
https://pubmed.ncbi.nlm.nih.gov/12965264
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....935ad94550751cb4511d3c89a1eaa81f
قاعدة البيانات: OpenAIRE
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