C-type natriuretic peptide plasma levels are reduced in obese adolescents
| العنوان: | C-type natriuretic peptide plasma levels are reduced in obese adolescents |
|---|---|
| المؤلفون: | Tommaso Prescimone, Chiara Caselli, Manuela Cabiati, Vanessa Bianchi, S. Del Ry, Giovanni Federico, Daniela Giannessi, Aldo Clerico, G. Saggese, Simona Storti |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Physiology, medicine.drug_class, Radioimmunoassay, Disease, Biochemistry, Cellular and Molecular Neuroscience, Endocrinology, Reference Values, Internal medicine, Natriuretic Peptide, Brain, medicine, Natriuretic peptide, Humans, Obesity, Child, business.industry, Healthy subjects, Natriuretic Peptide, C-Type, Plasma levels, medicine.disease, C-type natriuretic peptide, Cardiovascular Diseases, Heart failure, Female, business |
| الوصف: | The high prevalence of obesity in children may increase the magnitude of lifetime risk of cardiovascular disease (CD). At present, explicit data for recommending biomarkers as routine pre-clinical markers of CD in children are lacking. C-type natriuretic peptide (CNP) is assuming increasing importance in CD; in adults with heart failure, its plasma levels are related to clinical and functional disease severity. We have previously reported five different reference intervals for blood CNP as a function of age in healthy children; however, data on plasma CNP levels in obese children are still lacking. Aim of this study was to assess CNP levels in obese adolescents and verify whether they differ from healthy subjects. Plasma CNP was measured in 29 obese adolescents (age: 11.8 ± 0.4 years; BMI: 29.8 ± 0.82) by radioimmunoassay and compared with the reference values of healthy subjects. BNP was also measured. Both plasma CNP and BNP levels were significantly lower in the obese adolescents compared to the appropriate reference values (CNP: 3.4 ± 0.2 vs 13.6 ± 2.3 pg/ml, p |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87af449d9f81c62d9986c143bda21556 http://hdl.handle.net/11568/680263 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....87af449d9f81c62d9986c143bda21556 |
| قاعدة البيانات: | OpenAIRE |
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