Suppressing effect of WR-2721 on micronuclei induced by cyclophosphamide in mice
| العنوان: | Suppressing effect of WR-2721 on micronuclei induced by cyclophosphamide in mice |
|---|---|
| المؤلفون: | Lidia Mazur, Agnieszka Czyzewska |
| المصدر: | Teratogenesis, carcinogenesis, and mutagenesis. 15(3) |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Male, Erythrocytes, Cyclophosphamide, Ratón, Health, Toxicology and Mutagenesis, Pharmacology, Biology, Toxicology, Clastogen, Mice, Amifostine, In vivo, Genetics, medicine, Animals, Genetics (clinical), Micronuclei, Chromosome-Defective, cyclophosphamide (CP), Micronucleus Tests, modulation of clastogenicity, in vivo micronucleus assay, Peripheral blood, Oncology, Immunology, Toxicity, Micronucleus test, Mutation, mouse peripheral blood, thiol agent WR-2721, medicine.drug, Mutagens |
| الوصف: | The effect of WR-2721 against cyclophosphamide-induced clastogenicity was studied using the in vivo micronucleus assay. The frequency of micronuclei in polychromatic erythrocytes in the peripheral blood of mice treated with WR-2721 and cyclophosphamide (CP), each of the compounds at a dose of 200 mg/kg body weight, was evaluated during the 15-day period. The suppressing effect of WR-2721, given 30 min prior to cyclophosphamide administration, on micronuclei induced by the alkylating agent was demonstrated. The number of micronuclei was increased on day 1 after CP application and declined thereafter with the frequency of micronucleated polychromatic erythrocytes remaining lower in WR-2721 pre-treated mice. The modulatory effect of WR-2721 on the clastogenic activity of cyclophosphamide in the erythropoietic system by the mouse micronucleus test was shown. |
| تدمد: | 0270-3211 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bc2a1d26a26c405589e5c71d955e6e https://pubmed.ncbi.nlm.nih.gov/8584982 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....82bc2a1d26a26c405589e5c71d955e6e |
| قاعدة البيانات: | OpenAIRE |
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