Expression of α-Smooth Muscle Actin in Benign or Malignant Ovarian Tumors
| العنوان: | Expression of α-Smooth Muscle Actin in Benign or Malignant Ovarian Tumors |
|---|---|
| المؤلفون: | Toshiharu Kamura, Hiroaki Kobayashi, Tsunehisa Kaku, Koichiro Sugihara, Shun'ichiro Taniguchi, Nobuhiro Tsuruchi, Toshiaki Saito, Hitto Nakano, Naoki Tsukamoto |
| المصدر: | Gynecologic Oncology. 48:308-313 |
| بيانات النشر: | Elsevier BV, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Stromal cell, medicine.drug_class, Blotting, Western, Cystadenoma, Ovary, Adenocarcinoma, Biology, Monoclonal antibody, Muscle, Smooth, Vascular, Benign tumor, Western blot, medicine, Humans, Ovarian Neoplasms, medicine.diagnostic_test, Antibodies, Monoclonal, Obstetrics and Gynecology, medicine.disease, Immunohistochemistry, Actins, Blot, medicine.anatomical_structure, Oncology, Cancer cell, Electrophoresis, Polyacrylamide Gel, Female |
| الوصف: | We compared the expression of alpha-smooth muscle actin (alpha-SMA) between benign and malignant human ovarian tissues by immunohistochemical staining and Western blot analysis using the monoclonal antibody specific to alpha-SMA. In normal human ovaries, alpha-SMA was found in the blood vessel walls, muscle fibers, and stromal cells surrounding the follicles. The main source of alpha-SMA in the benign ovarian tumors was the blood vessel walls which highly expressed the alpha-SMA throughout the tumor. In malignant tumor tissues, however, the vessels located in or close to the cluster of cancer cells did not express alpha-SMA. It corresponded to the results of the Western blot analysis, showing that the amount of alpha-SMA in malignant ovarian tumor tissues was much smaller than that in benign tumor tissues. Thus, the alteration in alpha-SMA expression seems to reflect the qualitative difference in vessels between benign and malignant ovarian tissues, and therefore alpha-SMA is considered to potentially be a histopathologically useful marker for indicating the malignant potential of ovarian tumors. |
| تدمد: | 0090-8258 |
| DOI: | 10.1006/gyno.1993.1054 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820030319e32db23fea3da36b64237d5 https://doi.org/10.1006/gyno.1993.1054 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....820030319e32db23fea3da36b64237d5 |
| قاعدة البيانات: | OpenAIRE |
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