Enhancing the Therapeutic Efficacy of Bortezomib in Cancer Therapy Using Polymeric Nanostructures
| العنوان: | Enhancing the Therapeutic Efficacy of Bortezomib in Cancer Therapy Using Polymeric Nanostructures |
|---|---|
| المؤلفون: | Amirhossein Sahebkar, Hossein M. Orafai, Shahla Korani, Thomas P. Johnston, Elham Zendehdel, Mahmoud Reza Jaafari, Amin Reza Nikpoor, Mitra Korani |
| المصدر: | Current pharmaceutical design. 25(46) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Angiogenesis, Polymers, Antineoplastic Agents, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Bortezomib, Drug Delivery Systems, Neoplasms, Drug Discovery, medicine, Humans, Multiple myeloma, Pharmacology, business.industry, 021001 nanoscience & nanotechnology, medicine.disease, 0104 chemical sciences, Nanostructures, Proteasome, Drug delivery, Cancer research, Proteasome inhibitor, Mantle cell lymphoma, Nanocarriers, 0210 nano-technology, business, Proteasome Inhibitors, medicine.drug |
| الوصف: | Bortezomib (VELCADE®) is a boronate peptide and first-in-class proteasome inhibitor serving an important role in degenerating several intracellular proteins. It is a reversible inhibitor of the 26S proteasome, with antitumor activity and antiproliferative properties. This agent principally exerts its antineoplastic effects by inhibiting key players in the nuclear factor κB (NFκB) pathway involved in cell proliferation, apoptosis, and angiogenesis. This medication is used in the management of multiple myeloma. However, more recently, it has been used as a therapeutic option for mantle cell lymphoma. While promising, bortezomib has limited clinical applications due to its adverse effects (e.g., hematotoxicity and peripheral neuropathy) and low effectiveness in solid tumors resulting from its poor penetration into such masses and suboptimal pharmacokinetic parameters. Other limitations to bortezomib include its low chemical stability and bioavailability, which can be overcome by using nanoparticles for its delivery. Nanoparticle delivery systems can facilitate the targeted delivery of chemotherapeutic agents in high doses to the target site, while sparing healthy tissues. Therefore, this drug delivery system has provided a solution to circumvent the limitations faced with the delivery of traditional cancer chemotherapeutic agents. Our aim in this review was to describe polymer-based nanocarriers that can be used for the delivery of bortezomib in cancer chemotherapy. |
| تدمد: | 1873-4286 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81134a8acfb8f8edaedc352d8a5435b0 https://pubmed.ncbi.nlm.nih.gov/31692424 |
| رقم الانضمام: | edsair.doi.dedup.....81134a8acfb8f8edaedc352d8a5435b0 |
| قاعدة البيانات: | OpenAIRE |
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