An alpha-fetoprotein-producing human gallbladder carcinoma cell line (KMG-C) shows more aggressive biologic behavior than an alpha-fetoprotein-non-producing cell line
| العنوان: | An alpha-fetoprotein-producing human gallbladder carcinoma cell line (KMG-C) shows more aggressive biologic behavior than an alpha-fetoprotein-non-producing cell line |
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| المؤلفون: | Toru Hisaka, Hirohisa Yano, Masafumi Maruiwa, Kazunori Fukuda, Masamichi Kojiro, Rin Yamaguchi, Sachiko Ogasawara |
| المصدر: | International journal of oncology. 8(6) |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, Cell, Cell cycle, Biology, medicine.disease, digestive system diseases, medicine.anatomical_structure, Carcinoembryonic antigen, Oncology, Carcinoma, medicine, Cancer research, biology.protein, Doubling time, Adenocarcinoma, Alpha-fetoprotein, A431 cells |
| الوصف: | We have established a new human alphafetoprotein (AFP)-producing gallbladder carcinoma (GBC) cell line, termed KMG-C, from a 67-year-old Japanese male. KMG-C and its reconstituted tumors in nude mice showed the morphological features of an adenocarcinoma. Functionally, KMG-C secreted AFP, carcinoembryonic antigen, and carbohydrate antigen 19-9, as well as 7 serum proteins, including albumin and C-reactive protein. KMG-C showed more malignant biological behavior than an AFP-nonproducing GBC cell line, KMG-A, established originally from the tumor of the same patient; KMG-C had a shorter doubling time, higher tumorigenicity, and an aneuploid DNA index. Our results suggest that AFP-producing GBC cells may have more malignant biological characteristics than AFP-non-producing GBC cells in GBCs having both of these components. |
| تدمد: | 1019-6439 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78deaf1cabbb0c38ba123b9fdfbf63cb https://pubmed.ncbi.nlm.nih.gov/21544480 |
| رقم الانضمام: | edsair.doi.dedup.....78deaf1cabbb0c38ba123b9fdfbf63cb |
| قاعدة البيانات: | OpenAIRE |
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