Delivery of siRNA based on engineered exosomes for glioblastoma therapy by targeting STAT3
| العنوان: | Delivery of siRNA based on engineered exosomes for glioblastoma therapy by targeting STAT3 |
|---|---|
| المؤلفون: | Shi-Fu Liang, Fang-Fang Zuo, Bin-Cheng Yin, Bang-Ce Ye |
| المصدر: | Biomaterials science. 10(6) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | STAT3 Transcription Factor, Mice, Blood-Brain Barrier, Cell Line, Tumor, Biomedical Engineering, Animals, Humans, Mice, Nude, General Materials Science, RNA, Small Interfering, Exosomes, Glioblastoma |
| الوصف: | Small interfering RNA (siRNA) therapy has been considered as a promising strategy for treatment of glioblastoma (GBM), which is an aggressive brain disease with poor prognosis. However, siRNA therapy for GBM is seriously hindered by a multitude of barriers including possible immunogenicity, poor cellular uptake, short blood circulation, poor blood stability and low blood-brain barrier (BBB) penetration. This paper reports Angiopep-2 (An2)-functionalized signal transducers and activators of transcription 3 (STAT3) siRNA-loaded exosomes (Exo-An2-siRNA) as potential therapeutic agents to improve GBM therapy. The experimental results indicate that Exo-An2-siRNA displays high blood stability, efficient cellular uptake, and outstanding BBB penetration ability. Exo-An2-siRNA also exhibits excellent |
| تدمد: | 2047-4849 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1d63d261b851bd675c0dcc32cd27e1 https://pubmed.ncbi.nlm.nih.gov/35179533 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6c1d63d261b851bd675c0dcc32cd27e1 |
| قاعدة البيانات: | OpenAIRE |
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