Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians
| العنوان: | Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians |
|---|---|
| المؤلفون: | Susan E. Beekmann, Adi V. Gundlapalli, Donald R. Graham, Philip M. Polgreen |
| المصدر: | Open Forum Infectious Diseases |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, 030106 microbiology, antimicrobial agents, Pharmacy, Economic shortage, Meropenem, 03 medical and health sciences, Patient safety, 0302 clinical medicine, Major Article, patient safety, medicine, Antimicrobial stewardship, 030212 general & internal medicine, Notice, business.industry, medicine.disease, Antimicrobial, 3. Good health, Infectious Diseases, Oncology, Medical emergency, Norm (social), business, shortages, medicine.drug |
| الوصف: | Background In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of antimicrobial agents. Methods We used a web-based survey of ID physician members of the Emerging Infections Network in 2016. Results Of the 701 of 1597 members (44%) who responded, 70% reported the need to modify their antimicrobial choice because of a shortage in the prior 2 years. A majority (73%) reported the shortages affected patient care or outcomes by the use of broader-spectrum (75%), more costly (58%), less effective second-line (45%), or more toxic agents (37%). The most commonly reported antimicrobials in short supply were piperacillin-tazobactam, ampicillin-sulbactam, meropenem, cefotaxime, and cefepime. Respondents learned of shortages from hospital notification, from a colleague, contact from pharmacy after ordering the agent in short supply, or FDA or other website. The antimicrobial stewardship programs (ASPs) of a majority (83%) of respondents’ institutions had developed approaches to deal with shortages. Although 71% indicated that communications were sufficient, most (87%) did not perceive any improvement in communications about shortages since the 2012 FDA requirement. Conclusions The persistence of antimicrobial agent shortages reported by ID physicians is disturbing as is the resulting need to use broader-spectrum or more toxic agents. The prominent role of ASPs in helping to deal with shortages, effective communication channels, and the lack of perceived improvement in FDA’s communication strategy merit further consideration. |
| تدمد: | 2328-8957 |
| DOI: | 10.1093/ofid/ofy068 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc44b9b689bafc286a9745df2d651de https://doi.org/10.1093/ofid/ofy068 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6bc44b9b689bafc286a9745df2d651de |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi.dedup.....6bc44b9b689bafc286a9745df2d651de 818 3 unknown 818.374145507813 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....6bc44b9b689bafc286a9745df2d651de&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc44b9b689bafc286a9745df2d651de# [Name] => EDS - OpenAIRE [Category] => fullText [Text] => View record in OpenAIRE [MouseOverText] => View record in OpenAIRE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Susan+E%2E+Beekmann%22">Susan E. Beekmann</searchLink><br /><searchLink fieldCode="AR" term="%22Adi+V%2E+Gundlapalli%22">Adi V. Gundlapalli</searchLink><br /><searchLink fieldCode="AR" term="%22Donald+R%2E+Graham%22">Donald R. Graham</searchLink><br /><searchLink fieldCode="AR" term="%22Philip+M%2E+Polgreen%22">Philip M. Polgreen</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Open Forum Infectious Diseases ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Oxford University Press (OUP), 2018. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2018 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%220301+basic+medicine%22">0301 basic medicine</searchLink><br /><searchLink fieldCode="DE" term="%22030106+microbiology%22">030106 microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22antimicrobial+agents%22">antimicrobial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacy%22">Pharmacy</searchLink><br /><searchLink fieldCode="DE" term="%22Economic+shortage%22">Economic shortage</searchLink><br /><searchLink fieldCode="DE" term="%22Meropenem%22">Meropenem</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+safety%22">Patient safety</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Major+Article%22">Major Article</searchLink><br /><searchLink fieldCode="DE" term="%22patient+safety%22">patient safety</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Antimicrobial+stewardship%22">Antimicrobial stewardship</searchLink><br /><searchLink fieldCode="DE" term="%22030212+general+%26+internal+medicine%22">030212 general & internal medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Notice%22">Notice</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Antimicrobial%22">Antimicrobial</searchLink><br /><searchLink fieldCode="DE" term="%223%2E+Good+health%22">3. Good health</searchLink><br /><searchLink fieldCode="DE" term="%22Infectious+Diseases%22">Infectious Diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Oncology%22">Oncology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+emergency%22">Medical emergency</searchLink><br /><searchLink fieldCode="DE" term="%22Norm+%28social%29%22">Norm (social)</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink><br /><searchLink fieldCode="DE" term="%22shortages%22">shortages</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edrug%22">medicine.drug</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Background In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of antimicrobial agents. Methods We used a web-based survey of ID physician members of the Emerging Infections Network in 2016. Results Of the 701 of 1597 members (44%) who responded, 70% reported the need to modify their antimicrobial choice because of a shortage in the prior 2 years. A majority (73%) reported the shortages affected patient care or outcomes by the use of broader-spectrum (75%), more costly (58%), less effective second-line (45%), or more toxic agents (37%). The most commonly reported antimicrobials in short supply were piperacillin-tazobactam, ampicillin-sulbactam, meropenem, cefotaxime, and cefepime. Respondents learned of shortages from hospital notification, from a colleague, contact from pharmacy after ordering the agent in short supply, or FDA or other website. The antimicrobial stewardship programs (ASPs) of a majority (83%) of respondents’ institutions had developed approaches to deal with shortages. Although 71% indicated that communications were sufficient, most (87%) did not perceive any improvement in communications about shortages since the 2012 FDA requirement. Conclusions The persistence of antimicrobial agent shortages reported by ID physicians is disturbing as is the resulting need to use broader-spectrum or more toxic agents. The prominent role of ASPs in helping to deal with shortages, effective communication channels, and the lack of perceived improvement in FDA’s communication strategy merit further consideration. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2328-8957 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1093/ofid/ofy068 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc44b9b689bafc286a9745df2d651de" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc44b9b689bafc286a9745df2d651de</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1093/ofid/ofy068" linkWindow="_blank">https://doi.org/10.1093/ofid/ofy068</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....6bc44b9b689bafc286a9745df2d651de ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1093/ofid/ofy068
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => 0301 basic medicine
[Type] => general
)
[1] => Array
(
[SubjectFull] => 030106 microbiology
[Type] => general
)
[2] => Array
(
[SubjectFull] => antimicrobial agents
[Type] => general
)
[3] => Array
(
[SubjectFull] => Pharmacy
[Type] => general
)
[4] => Array
(
[SubjectFull] => Economic shortage
[Type] => general
)
[5] => Array
(
[SubjectFull] => Meropenem
[Type] => general
)
[6] => Array
(
[SubjectFull] => 03 medical and health sciences
[Type] => general
)
[7] => Array
(
[SubjectFull] => Patient safety
[Type] => general
)
[8] => Array
(
[SubjectFull] => 0302 clinical medicine
[Type] => general
)
[9] => Array
(
[SubjectFull] => Major Article
[Type] => general
)
[10] => Array
(
[SubjectFull] => patient safety
[Type] => general
)
[11] => Array
(
[SubjectFull] => medicine
[Type] => general
)
[12] => Array
(
[SubjectFull] => Antimicrobial stewardship
[Type] => general
)
[13] => Array
(
[SubjectFull] => 030212 general & internal medicine
[Type] => general
)
[14] => Array
(
[SubjectFull] => Notice
[Type] => general
)
[15] => Array
(
[SubjectFull] => business.industry
[Type] => general
)
[16] => Array
(
[SubjectFull] => medicine.disease
[Type] => general
)
[17] => Array
(
[SubjectFull] => Antimicrobial
[Type] => general
)
[18] => Array
(
[SubjectFull] => 3. Good health
[Type] => general
)
[19] => Array
(
[SubjectFull] => Infectious Diseases
[Type] => general
)
[20] => Array
(
[SubjectFull] => Oncology
[Type] => general
)
[21] => Array
(
[SubjectFull] => Medical emergency
[Type] => general
)
[22] => Array
(
[SubjectFull] => Norm (social)
[Type] => general
)
[23] => Array
(
[SubjectFull] => business
[Type] => general
)
[24] => Array
(
[SubjectFull] => shortages
[Type] => general
)
[25] => Array
(
[SubjectFull] => medicine.drug
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Susan E. Beekmann
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Adi V. Gundlapalli
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Donald R. Graham
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Philip M. Polgreen
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 04
[Type] => published
[Y] => 2018
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 23288957
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 5
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Open Forum Infectious Diseases
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |