Fluorine-18-Labeled Phospholipid Quantum Dot Micelles for in Vivo Multimodal Imaging from Whole Body to Cellular Scales
| العنوان: | Fluorine-18-Labeled Phospholipid Quantum Dot Micelles for in Vivo Multimodal Imaging from Whole Body to Cellular Scales |
|---|---|
| المؤلفون: | Bertrand Tavitian, Benoit Mahler, Françoise Hinnen, Laurence Herin, Frédéric Ducongé, Bertrand Kuhnast, Benoit Thézé, Carine Pestourie, Frédéric Dollé, Benoit Dubertret, Thomas Pons, Karine Gombert |
| المصدر: | Bioconjugate Chemistry. 19:1921-1926 |
| بيانات النشر: | American Chemical Society (ACS), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Diagnostic Imaging, Fluorine Radioisotopes, Fluorescence-lifetime imaging microscopy, Biodistribution, Biomedical Engineering, Phospholipid, Mice, Nude, Pharmaceutical Science, Bioengineering, Micelle, Mice, chemistry.chemical_compound, Nuclear magnetic resonance, In vivo, Quantum Dots, Cadmium Compounds, Animals, Nanotechnology, Whole Body Imaging, Selenium Compounds, Micelles, Phospholipids, Pharmacology, chemistry.chemical_classification, Biomolecule, Cell Membrane, Organic Chemistry, Nanostructures, Kinetics, Microscopy, Fluorescence, chemistry, Quantum dot, Positron-Emission Tomography, Preclinical imaging, Biotechnology |
| الوصف: | We have designed new nanoprobes applicable for both positron emission tomography (PET) and optical fluorescence in vivo imaging. Fluorine-18, which is commonly used for clinical imaging, has been coupled to phospholipid quantum dot (QD) micelles. This probe was injected in mice and we demonstrated that its dynamic quantitative whole body biodistribution and pharmacokinetics could be monitored using PET as well as the kinetics of their cellular uptake using in vivo fibered confocal fluorescence imaging. Phospholipid micelle encapsulation of QDs provides a highly versatile surface chemistry to conjugate multiple chemicals and biomolecules with controlled QD:molecule valency. Here, we show that, in contrast with several previous studies using other QD polymer coatings, these phospholipid QD micelles exhibit long circulation half-time in the bloodstream (on the order of 2 h) and slow uptake by reticulo-endothelial system. |
| تدمد: | 1520-4812 1043-1802 |
| DOI: | 10.1021/bc800179j |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b649a85413bacd4b440e0c132cd4684 https://doi.org/10.1021/bc800179j |
| رقم الانضمام: | edsair.doi.dedup.....6b649a85413bacd4b440e0c132cd4684 |
| قاعدة البيانات: | OpenAIRE |
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