Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease
| العنوان: | Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease |
|---|---|
| المؤلفون: | Eleonora Ambrad Giovannetti, Martin Fuhrmann |
| المصدر: | Brain research 1707, 216-226 (2019). doi:10.1016/j.brainres.2018.11.042 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, metabolism [GABAergic Neurons], metabolism [Amyloid beta-Peptides], Context (language use), tau Proteins, physiopathology [Alzheimer Disease], Synapse, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Memory, Biological neural network, physiopathology [Nerve Net], Medicine, Memory impairment, Animals, Humans, pathology [Memory Disorders], ddc:610, metabolism [gamma-Aminobutyric Acid], GABAergic Neurons, Molecular Biology, physiology [Memory], Neuroinflammation, gamma-Aminobutyric Acid, Neurons, Memory Disorders, Amyloid beta-Peptides, Microglia, business.industry, General Neuroscience, pathology [Nerve Degeneration], Brain, metabolism [tau Proteins], Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, nervous system, metabolism [Brain], metabolism [Neurons], Nerve Degeneration, Cholinergic, GABAergic, Neurology (clinical), Nerve Net, business, Neuroscience, 030217 neurology & neurosurgery, Developmental Biology |
| الوصف: | Alzheimer's disease (AD) is characterized by the classical hallmarks of Aβ-deposition and tau-pathology that are thought to ultimately lead to synapse and neuron loss. Although long known, neuroinflammation has recently attracted a substantial amount of attention by researchers due to genome wide association studies (GWAS) that identified microglia associated genes to be correlated with sporadic AD. Besides that, cholinergic degeneration and gamma-aminobutyric acid (GABA) abnormalities have been identified in the brains of AD patients already decades ago, but have not received much attention over the last ten years. Recently, the neuronal network dysfunction hypothesis has revived interest in how impairments of neuronal communication at the network level lead to epileptiform activity and disrupted oscillations observed in the brains of AD patients and mouse models. Thereby, deficits in neuronal networks involved in learning and memory might ultimately cause memory impairments. In this context, an imbalance between excitation and inhibition has been hypothesized to contribute to neuronal network dysfunction. Here, disturbances of cholinergic and GABAergic transmission might play a crucial role. In this review, we will focus on GABAergic dysfunction in AD and mouse models of AD and how those might relate to neuronal network aberration and memory impairment. |
| تدمد: | 1872-6240 |
| DOI: | 10.1016/j.brainres.2018.11.042 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a255bc2a5307e9361577208012c6d37 https://pubmed.ncbi.nlm.nih.gov/30503351 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a255bc2a5307e9361577208012c6d37 |
| قاعدة البيانات: | OpenAIRE |
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