Triphenylbismuth dichloride inhibits human glyoxalase I and induces cytotoxicity in cultured cancer cell lines
| العنوان: | Triphenylbismuth dichloride inhibits human glyoxalase I and induces cytotoxicity in cultured cancer cell lines |
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| المؤلفون: | Ryoko Takasawa, Akane Jona, Manami Inoue, Miku Azuma, Haruka Akahane, Yuto Ueno, Yuki Nakagawa, Ryusei Chimori, Yasunari Mano, Yuki Murata, Shuji Yasuike, Toshiyuki Kaji |
| المصدر: | The Journal of toxicological sciences. 47(12) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Lung Neoplasms, Lactoylglutathione Lyase, Humans, HL-60 Cells, Toxicology, Pyruvaldehyde, Bismuth |
| الوصف: | Organobismuth compounds, i.e., organic-inorganic hybrid molecules composed of an organic structure and bismuth metal, have been reported to induce cytotoxicity in cancer cells; however, the target proteins associated with this cytotoxicity have not been elucidated. Herein, we investigated the inhibitory effect of five organobismuth compounds on human glyoxalase I (hGLO I), a promising target candidate for cancer therapy. Among these compounds, triphenylbismuth dichloride (Bi-05) exerted a strong inhibitory effect on hGLO I. Indeed, Bi-05 inhibited hGLO I in a dose-dependent manner with an IC |
| تدمد: | 1880-3989 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6672aed24eadc09197438b39f6a1b27a https://pubmed.ncbi.nlm.nih.gov/36450498 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6672aed24eadc09197438b39f6a1b27a |
| قاعدة البيانات: | OpenAIRE |
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