Immunological Control of HIV-1 Disease Progression by Rare Protective HLA Allele
| العنوان: | Immunological Control of HIV-1 Disease Progression by Rare Protective HLA Allele |
|---|---|
| المؤلفون: | Yu Zhang, Takayuki Chikata, Nozomi Kuse, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi |
| المصدر: | Journal of virology. 96(22) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Immunology, Epitopes, T-Lymphocyte, HIV Infections, CD8-Positive T-Lymphocytes, Virus Replication, Microbiology, Epitopes, HLA-B Antigens, Virology, Insect Science, HIV Seropositivity, HIV-1, Disease Progression, Humans, Alleles |
| الوصف: | HLA-B57 is a relatively rare allele around world and the strongest protective HLA allele in Caucasians and African black individuals infected with HIV-1. Previous studies suggested that the advantage of this allele in HIV-1 disease progression is due to a strong functional ability of HLA-B57-restricted Gag-specific T cells and lower fitness of mutant viruses selected by the T cells. |
| تدمد: | 1098-5514 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656e68a57aaa2a3c11fb054102395af6 https://pubmed.ncbi.nlm.nih.gov/36326273 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....656e68a57aaa2a3c11fb054102395af6 |
| قاعدة البيانات: | OpenAIRE |
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