Regulation of Insulin-like Growth Factor-I in Starvation and Injury
| العنوان: | Regulation of Insulin-like Growth Factor-I in Starvation and Injury |
|---|---|
| المؤلفون: | Jean-Paul Thissen, Jean-Marie Ketelslegers, Louis E. Underwood |
| المصدر: | Nutrition Reviews. 57:167-176 |
| بيانات النشر: | Oxford University Press (OUP), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Anabolism, medicine.medical_treatment, Medicine (miscellaneous), Biology, Anabolic Agents, Sepsis, Insulin-like growth factor, Internal medicine, medicine, Humans, Insulin, Insulin-Like Growth Factor I, Glucocorticoids, Starvation, Nutrition and Dietetics, Human Growth Hormone, Catabolism, Growth factor, medicine.disease, Somatropin, Endocrinology, medicine.symptom, Energy Intake |
| الوصف: | Both starvation and sepsis are characterized by growth hormone (GH) insensitivity, which leads to a reduction in circulating insulin-like growth factor (IGF)-I. Because of the anabolic properties of this growth factor, its decline may contribute to the growth arrest and the catabolic reaction observed in starvation and sepsis. This review focuses on the mechanisms responsible for the reduction in circulating IGF-I and impairment of GH responsiveness that occur during starvation and sepsis. A clearer understanding of the complex nature of GH resistance should lead to the development of new therapeutic strategies aimed at restoring the beneficial effects of anabolic agents such as GH and IGF-I. |
| تدمد: | 1753-4887 0029-6643 |
| DOI: | 10.1111/j.1753-4887.1999.tb06939.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6164c1602ad994a95a2b1ed31bc41491 https://doi.org/10.1111/j.1753-4887.1999.tb06939.x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6164c1602ad994a95a2b1ed31bc41491 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17534887 00296643 |
|---|---|
| DOI: | 10.1111/j.1753-4887.1999.tb06939.x |