Iron deficiency in pulmonary arterial hypertension: A matter of definition!
| العنوان: | Iron deficiency in pulmonary arterial hypertension: A matter of definition! |
|---|---|
| المؤلفون: | J Löffler-Ragg, E Rieger, K Cima, T Sonnweber, G Weiss |
| المصدر: | 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases. |
| بيانات النشر: | European Respiratory Society, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, biology, business.industry, Hemodynamics, Retrospective cohort study, Iron deficiency, medicine.disease, Gastroenterology, Pathophysiology, Ferritin, Internal medicine, Cohort, medicine, biology.protein, Hemoglobin, business, Soluble transferrin receptor |
| الوصف: | Background: Iron deficiency (ID) plays an important role in chronic disease modulation. There is increasing interest in the role of iron homeostasis in the natural history of pulmonary arterial hypertension (PAH). Methods: In a retrospective study in 84 patients with PAH the presence of ID was assessed according to four different definitions: (1) soluble transferrin receptor (sTfR) >2.07mg/l, (2) ferritin Results: The frequency of ID varied depending on its definition. All PAH patients displayed elevated sTfR (100%, mean 4.41 +/-2.19mg/l), whereas according to the stringent definition (2) only 9.9% of the PAH patients were iron deficient. The criteria for ID in left heart disease (3) displayed 37,0% to have a lack of iron and applying ferritin index (4) 38,3% of the PAH patients showed evidence of ID. In contrast to definition (1) and (2) the use of criteria (3) and (4) showed a significant difference between patients with normal iron status and patients lacking iron in exercise capacity as reflected by differences in 6 minute walk distance and NYHA functional class, hemodynamic parameters such as PVR, and blood testing with significant differences in hemoglobin and NT-proBNP levels. Conclusion: The frequency of ID in our cohort of PAH patients shows pronounced differences depending on its definition. The issue of the most suitable definition of ID in PAH complicates the interpretation of the role of iron homeostasis in the pathophysiology of PAH. |
| DOI: | 10.1183/13993003.congress-2016.pa1879 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603967f44e202671e50f649f6888e9ec https://doi.org/10.1183/13993003.congress-2016.pa1879 |
| رقم الانضمام: | edsair.doi.dedup.....603967f44e202671e50f649f6888e9ec |
| قاعدة البيانات: | OpenAIRE |
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