Preliminary investigation of novel tetra-tailed macrocycle amphiphile based nano-vesicles for amphotericin B improved oral pharmacokinetics
| العنوان: | Preliminary investigation of novel tetra-tailed macrocycle amphiphile based nano-vesicles for amphotericin B improved oral pharmacokinetics |
|---|---|
| المؤلفون: | Heyam Saad Ali, Babiker M. El-Haj, Muhammad Imran, Shafi Ullah, Jawad ur Rehman, Imdad Ali, Ibrahim Javed, Muhammad Raza Shah, Muhammad Arfan |
| المصدر: | Artificial Cells, Nanomedicine, and Biotechnology. 46:1204-1214 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Biocompatibility, Biomedical Engineering, Administration, Oral, Pharmaceutical Science, Medicine (miscellaneous), 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Mice, Amphotericin B, Cell Line, Tumor, Amphiphile, Animals, Humans, Drug Carriers, Chemistry, Vesicle, General Medicine, Resorcinarene, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Bioavailability, Critical micelle concentration, Drug delivery, NIH 3T3 Cells, Nanoparticles, Rabbits, Nanocarriers, 0210 nano-technology, Biotechnology, Nuclear chemistry |
| الوصف: | Supramolecular macrocycles-based drug delivery systems are receiving wider recognition due to their self-assembly into nanostructures with unique characteristics. This study reports synthesis of resorcinarene-based novel and biocompatible amphiphilic supramolecular macrocycle that self-assembles into nano-vesicular system for Amphotericin B (Am-B) delivery, a model hydrophobic drug. The macrocycle was synthesized through a two-step reaction and was characterized with 1H NMR and mass spectrometric techniques. Its biocompatibility was assessed in cancer cell lines, blood and animals. Its critical micelle concentration (CMC) was determined using UV spectrophotometer. Am-B loaded in novel macrocycle-based vesicles were examined according to their shape, size, surface charge, drug entrapment efficiency and excepients compatibility using atomic force microscope (AFM), Zetasizer, HPLC and FT-IR spectroscopy. Drug-loaded vesicles were also investigated for their in-vitro release, stability and in-vivo oral bioavailability in rabbits. The macrocycle was found to be nontoxic against cancer cells, haemo-compatible and safe in mice and revealed lower CMC. It formed mono-dispersed spherical shape vesicles of 174.4 +/- 3.78nm in mean size. Vesicles entrapped 92.05 +/- 4.39% drug and were stable upon storage with gastric-simulated fluid and increased the drug oral bioavailability in rabbits. Results confirmed novel macrocycle as biocompatible vesicular nanocarrier for enhancing the oral bioavailability of lipophilic drugs. |
| تدمد: | 2169-141X 2169-1401 |
| DOI: | 10.1080/21691401.2018.1536061 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b99101012e85e929403cdff1ee8e9cd https://doi.org/10.1080/21691401.2018.1536061 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b99101012e85e929403cdff1ee8e9cd |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi.dedup.....5b99101012e85e929403cdff1ee8e9cd 843 3 unknown 843.468811035156 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....5b99101012e85e929403cdff1ee8e9cd&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b99101012e85e929403cdff1ee8e9cd# [Name] => EDS - OpenAIRE [Category] => fullText [Text] => View record in OpenAIRE [MouseOverText] => View record in OpenAIRE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Preliminary investigation of novel tetra-tailed macrocycle amphiphile based nano-vesicles for amphotericin B improved oral pharmacokinetics
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Heyam+Saad+Ali%22">Heyam Saad Ali</searchLink><br /><searchLink fieldCode="AR" term="%22Babiker+M%2E+El-Haj%22">Babiker M. El-Haj</searchLink><br /><searchLink fieldCode="AR" term="%22Muhammad+Imran%22">Muhammad Imran</searchLink><br /><searchLink fieldCode="AR" term="%22Shafi+Ullah%22">Shafi Ullah</searchLink><br /><searchLink fieldCode="AR" term="%22Jawad+ur+Rehman%22">Jawad ur Rehman</searchLink><br /><searchLink fieldCode="AR" term="%22Imdad+Ali%22">Imdad Ali</searchLink><br /><searchLink fieldCode="AR" term="%22Ibrahim+Javed%22">Ibrahim Javed</searchLink><br /><searchLink fieldCode="AR" term="%22Muhammad+Raza+Shah%22">Muhammad Raza Shah</searchLink><br /><searchLink fieldCode="AR" term="%22Muhammad+Arfan%22">Muhammad Arfan</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <i>Artificial Cells, Nanomedicine, and Biotechnology</i>. 46:1204-1214 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Informa UK Limited, 2018. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2018 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Biomedical+Engineering%22">Biomedical Engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Administration%2C+Oral%22">Administration, Oral</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+Science%22">Pharmaceutical Science</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine+%28miscellaneous%29%22">Medicine (miscellaneous)</searchLink><br /><searchLink fieldCode="DE" term="%2202+engineering+and+technology%22">02 engineering and technology</searchLink><br /><searchLink fieldCode="DE" term="%22010402+general+chemistry%22">010402 general chemistry</searchLink><br /><searchLink fieldCode="DE" term="%2201+natural+sciences%22">01 natural sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Amphotericin+B%22">Amphotericin B</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Line%2C+Tumor%22">Cell Line, Tumor</searchLink><br /><searchLink fieldCode="DE" term="%22Amphiphile%22">Amphiphile</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+Carriers%22">Drug Carriers</searchLink><br /><searchLink fieldCode="DE" term="%22Chemistry%22">Chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Vesicle%22">Vesicle</searchLink><br /><searchLink fieldCode="DE" term="%22General+Medicine%22">General Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Resorcinarene%22">Resorcinarene</searchLink><br /><searchLink fieldCode="DE" term="%22021001+nanoscience+%26+nanotechnology%22">021001 nanoscience & nanotechnology</searchLink><br /><searchLink fieldCode="DE" term="%220104+chemical+sciences%22">0104 chemical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Bioavailability%22">Bioavailability</searchLink><br /><searchLink fieldCode="DE" term="%22Critical+micelle+concentration%22">Critical micelle concentration</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery%22">Drug delivery</searchLink><br /><searchLink fieldCode="DE" term="%22NIH+3T3+Cells%22">NIH 3T3 Cells</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Rabbits%22">Rabbits</searchLink><br /><searchLink fieldCode="DE" term="%22Nanocarriers%22">Nanocarriers</searchLink><br /><searchLink fieldCode="DE" term="%220210+nano-technology%22">0210 nano-technology</searchLink><br /><searchLink fieldCode="DE" term="%22Biotechnology%22">Biotechnology</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+chemistry%22">Nuclear chemistry</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Supramolecular macrocycles-based drug delivery systems are receiving wider recognition due to their self-assembly into nanostructures with unique characteristics. This study reports synthesis of resorcinarene-based novel and biocompatible amphiphilic supramolecular macrocycle that self-assembles into nano-vesicular system for Amphotericin B (Am-B) delivery, a model hydrophobic drug. The macrocycle was synthesized through a two-step reaction and was characterized with 1H NMR and mass spectrometric techniques. Its biocompatibility was assessed in cancer cell lines, blood and animals. Its critical micelle concentration (CMC) was determined using UV spectrophotometer. Am-B loaded in novel macrocycle-based vesicles were examined according to their shape, size, surface charge, drug entrapment efficiency and excepients compatibility using atomic force microscope (AFM), Zetasizer, HPLC and FT-IR spectroscopy. Drug-loaded vesicles were also investigated for their in-vitro release, stability and in-vivo oral bioavailability in rabbits. The macrocycle was found to be nontoxic against cancer cells, haemo-compatible and safe in mice and revealed lower CMC. It formed mono-dispersed spherical shape vesicles of 174.4 +/- 3.78nm in mean size. Vesicles entrapped 92.05 +/- 4.39% drug and were stable upon storage with gastric-simulated fluid and increased the drug oral bioavailability in rabbits. Results confirmed novel macrocycle as biocompatible vesicular nanocarrier for enhancing the oral bioavailability of lipophilic drugs. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2169-141X<br />2169-1401 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1080/21691401.2018.1536061 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b99101012e85e929403cdff1ee8e9cd" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b99101012e85e929403cdff1ee8e9cd</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1080/21691401.2018.1536061" linkWindow="_blank">https://doi.org/10.1080/21691401.2018.1536061</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....5b99101012e85e929403cdff1ee8e9cd ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1080/21691401.2018.1536061
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 11
[StartPage] => 1204
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Biocompatibility
[Type] => general
)
[1] => Array
(
[SubjectFull] => Biomedical Engineering
[Type] => general
)
[2] => Array
(
[SubjectFull] => Administration, Oral
[Type] => general
)
[3] => Array
(
[SubjectFull] => Pharmaceutical Science
[Type] => general
)
[4] => Array
(
[SubjectFull] => Medicine (miscellaneous)
[Type] => general
)
[5] => Array
(
[SubjectFull] => 02 engineering and technology
[Type] => general
)
[6] => Array
(
[SubjectFull] => 010402 general chemistry
[Type] => general
)
[7] => Array
(
[SubjectFull] => 01 natural sciences
[Type] => general
)
[8] => Array
(
[SubjectFull] => Mice
[Type] => general
)
[9] => Array
(
[SubjectFull] => Amphotericin B
[Type] => general
)
[10] => Array
(
[SubjectFull] => Cell Line, Tumor
[Type] => general
)
[11] => Array
(
[SubjectFull] => Amphiphile
[Type] => general
)
[12] => Array
(
[SubjectFull] => Animals
[Type] => general
)
[13] => Array
(
[SubjectFull] => Humans
[Type] => general
)
[14] => Array
(
[SubjectFull] => Drug Carriers
[Type] => general
)
[15] => Array
(
[SubjectFull] => Chemistry
[Type] => general
)
[16] => Array
(
[SubjectFull] => Vesicle
[Type] => general
)
[17] => Array
(
[SubjectFull] => General Medicine
[Type] => general
)
[18] => Array
(
[SubjectFull] => Resorcinarene
[Type] => general
)
[19] => Array
(
[SubjectFull] => 021001 nanoscience & nanotechnology
[Type] => general
)
[20] => Array
(
[SubjectFull] => 0104 chemical sciences
[Type] => general
)
[21] => Array
(
[SubjectFull] => Bioavailability
[Type] => general
)
[22] => Array
(
[SubjectFull] => Critical micelle concentration
[Type] => general
)
[23] => Array
(
[SubjectFull] => Drug delivery
[Type] => general
)
[24] => Array
(
[SubjectFull] => NIH 3T3 Cells
[Type] => general
)
[25] => Array
(
[SubjectFull] => Nanoparticles
[Type] => general
)
[26] => Array
(
[SubjectFull] => Rabbits
[Type] => general
)
[27] => Array
(
[SubjectFull] => Nanocarriers
[Type] => general
)
[28] => Array
(
[SubjectFull] => 0210 nano-technology
[Type] => general
)
[29] => Array
(
[SubjectFull] => Biotechnology
[Type] => general
)
[30] => Array
(
[SubjectFull] => Nuclear chemistry
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Preliminary investigation of novel tetra-tailed macrocycle amphiphile based nano-vesicles for amphotericin B improved oral pharmacokinetics
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Heyam Saad Ali
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Babiker M. El-Haj
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Muhammad Imran
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Shafi Ullah
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jawad ur Rehman
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Imdad Ali
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ibrahim Javed
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Muhammad Raza Shah
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Muhammad Arfan
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 12
[M] => 11
[Type] => published
[Y] => 2018
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 2169141X
)
[1] => Array
(
[Type] => issn-print
[Value] => 21691401
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[3] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 46
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Artificial Cells, Nanomedicine, and Biotechnology
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |