Oncogenic heterogeneous nuclear ribonucleoprotein D-like promotes the growth of human colon cancer SW620 cells via its regulation of cell-cycle
| العنوان: | Oncogenic heterogeneous nuclear ribonucleoprotein D-like promotes the growth of human colon cancer SW620 cells via its regulation of cell-cycle |
|---|---|
| المؤلفون: | Dehuan Ji, Haixia Zhou, Yun Zhao, Hengli Ni, Xiaohui Hu, Zheng Zeng, Shibing Liao, Xiuyan Zhang, Wenjuan Ma, Pengshan Zhang |
| المصدر: | Acta Biochimica et Biophysica Sinica. 50:880-887 |
| بيانات النشر: | China Science Publishing & Media Ltd., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Heterogeneous nuclear ribonucleoprotein, Biophysics, Mice, Nude, Heterogeneous ribonucleoprotein particle, Biochemistry, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Animals, Humans, Cyclin D3, Cell Proliferation, Ribonucleoprotein, Chemistry, Cell Cycle, HEK 293 cells, Cancer, General Medicine, Middle Aged, Cell cycle, medicine.disease, Xenograft Model Antitumor Assays, Up-Regulation, Cell Transformation, Neoplastic, HEK293 Cells, RNAi Therapeutics, 030104 developmental biology, Ribonucleoproteins, Cell culture, 030220 oncology & carcinogenesis, Colonic Neoplasms, NIH 3T3 Cells, Cancer research, Female |
| الوصف: | Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins. Heterogeneous nuclear ribonucleoprotein D-like (HNRPDL) is a member of this family. Though aberrant expression of HNRPDL has been reported in a few cancers, whether HNRPDL is deregulated in colon cancer patients and what role this protein plays in these cells are not known yet. In this study, we found that HNRPDL was significantly up-regulated in colon cancer specimens than control. We also demonstrated that HNRPDL silencing inhibited the growth of SW620 cells both in vitro and in vivo. Conversely, we constructed a retroviral vector to deliver HNRPDL into non-malignant NIH-3T3 cells and injected these cells into nude mice. HNRPDL-overexpressing NIH-3T3 cells generated tumors in nude mice but not the control cells. Mechanistically, HNRPDL promoted cell-cycle progression associated with enhanced expressions of cyclin D3 and Ki-67 but decreased expressions of p53 and p21. Taken together, our data demonstrate that HNRPDL is aberrantly expressed in colon cancer cells, which promotes the growth of these cells by activating cell-cycle progression. |
| تدمد: | 1672-9145 |
| DOI: | 10.1093/abbs/gmy085 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0a9c097c6492a18856a754a4560c63 https://doi.org/10.1093/abbs/gmy085 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5a0a9c097c6492a18856a754a4560c63 |
| قاعدة البيانات: | OpenAIRE |
كن أول من يترك تعليقا!