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Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis

التفاصيل البيبلوغرافية
العنوان: Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis
المؤلفون: Vladimir Vasku, Monika Pávková Goldbergová, Zuzana Kozáčiková, Zbynek Splichal, Anna Vasku, Lydie IzakovičováHollá, Julie Bienertova-Vasku
المصدر: International journal of dermatology. 52(8)
سنة النشر: 2013
مصطلحات موضوعية: Adult, Male, Population, Dermatology, Human leukocyte antigen, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Psoriasis, Genotype, Medicine, Humans, Genetic Predisposition to Disease, Allele, Family history, ATP Binding Cassette Transporter, Subfamily B, Member 2, education, Lymphotoxin-alpha, 030304 developmental biology, Aged, Family Health, 0303 health sciences, education.field_of_study, Polymorphism, Genetic, business.industry, Tumor Necrosis Factor-alpha, Haplotype, Middle Aged, medicine.disease, Haplotypes, Immunology, ATP-Binding Cassette Transporters, Female, TAP1, business, Polymorphism, Restriction Fragment Length, 030215 immunology, HLA-DRB1 Chains
الوصف: Background The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1333 a/b, TAP1637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF] [-238 G/A] and NcoI TNF) with characteristics of family history in patients with psoriasis vulgaris. Materials and methods A total of 201 Czech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP1, TNF, and TNF genes (6p21.3) using the polymerase chain reaction-restriction fragment length polymorphism-based methodology. Results We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis (P-a=0.04). No differences related to family history of psoriasis were observed in HLA-DRB1*1501 polymorphism. As for the TNF (-238 G/A) polymorphism, a significant increase of the GG genotype was observed in patients, especially men with second- and third-degree relatives with psoriasis (P-g=0.008). Similarly, the B2B2 genotype of NcoI TNF polymorphism was more frequent in psoriatic patients, especially women, whose second- and third-degree relatives had psoriasis (P-g=0.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bcCB1A was different between not only men and women with psoriasis (P=0.007) but also between men and women without a family history of psoriasis (P=0.007). Conclusions Haplotype association of HLA gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases.
تدمد: 1365-4632
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5293b9049fe877d674221e89533cd683
https://pubmed.ncbi.nlm.nih.gov/23834030
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....5293b9049fe877d674221e89533cd683
قاعدة البيانات: OpenAIRE
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