أعرض في EDS

Sputum Trace Metals Are Biomarkers of Inflammatory and Suppurative Lung Disease

التفاصيل البيبلوغرافية
العنوان: Sputum Trace Metals Are Biomarkers of Inflammatory and Suppurative Lung Disease
المؤلفون: Andrew P. Greening, Donald Noble, M. Imrie, Dennis St. J. O'Reilly, Robert D. Gray, A. Christopher Boyd, David J. Porteous, Andrew Duncan, J. Alastair Innes
المصدر: Gray, R D, Duncan, A, Noble, D, Imrie, M, O'Reilly, D S, Innes, J A, Porteous, D J, Greening, A P & Boyd, A C 2010, ' Sputum trace metals are biomarkers of inflammatory and suppurative lung disease ', Chest, vol. 137, no. 3, pp. 635-641 . https://doi.org/10.1378/chest.09-1047
بيانات النشر: Elsevier BV, 2010.
سنة النشر: 2010
مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, Adult Aged Asthma/*diagnosis/metabolism Biological Markers/*analysis Bronchiectasis/*diagnosis/metabolism Copper/analysis Cystic Fibrosis/*diagnosis/metabolism Diagnosis, Differential Female Humans Iron/analysis Male Manganese/analysis Middle Aged Pulmonary Disease, Chronic Obstructive/*diagnosis/metabolism Reproducibility of Results Spectrum Analysis Sputum/*chemistry Suppuration Trace Elements/*analysis Zinc/analysis, Cystic Fibrosis, Exacerbation, Iron, Inflammation, Critical Care and Intensive Care Medicine, Cystic fibrosis, Diagnosis, Differential, Pulmonary Disease, Chronic Obstructive, Humans, Medicine, Aged, Asthma, Manganese, COPD, Suppuration, Bronchiectasis, business.industry, Spectrum Analysis, Respiratory disease, Sputum, Reproducibility of Results, Middle Aged, medicine.disease, Trace Elements, respiratory tract diseases, Zinc, Immunology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Biomarkers, Copper
الوصف: Background: Induced sputum cytology and protein biomarkers can be used to assess airways infl ammation. Increases in sputum iron have been described in infl ammatory lung disease. We hypothesized that other sputum metals may be affected by airways infl ammation and investigated their potential value as biomarkers. Methods: Sputum was obtained from 20 healthy control subjects and from patients with infl ammatory pulmonary diseases (23 with cystic fi brosis [CF], 16 with bronchiectasis, 17 with asthma, and 23 with COPD), and iron, zinc, manganese, and copper were measured. Fourteen patients with CF were also studied through an exacerbation cycle. Results: Sputum zinc and iron were elevated in CF and non-CF bronchiectasis vs controls ( P , .001, zinc; P , .01 iron). Manganese was elevated in asthma ( P , .01) and bronchiectasis ( P , .05) vs controls. Copper was elevated in CF vs controls ( P , .05). Zinc decreased ( P , .01) following treatment of CF exacerbation. In subjects with CF zinc levels correlated with other biomarkers. Conclusions: These results suggest a relationship of high concentrations of total zinc and iron with airways infl ammation in CF and non-CF bronchiectasis, with longitudinal changes being observed in CF. Further work is required to elucidate potential infl ammatory mechanisms related to these observations. CHEST 2010; 137(3):635–641
وصف الملف: application/pdf
تدمد: 0012-3692
DOI: 10.1378/chest.09-1047
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f73e8d586ccb5edf44db66efd50baf
https://doi.org/10.1378/chest.09-1047
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....51f73e8d586ccb5edf44db66efd50baf
قاعدة البيانات: OpenAIRE
ResultId 1
Header edsair
OpenAIRE
edsair.doi.dedup.....51f73e8d586ccb5edf44db66efd50baf
793
3

unknown
793.350891113281
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....51f73e8d586ccb5edf44db66efd50baf&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f73e8d586ccb5edf44db66efd50baf# [Name] => EDS - OpenAIRE [Category] => fullText [Text] => View record in OpenAIRE [MouseOverText] => View record in OpenAIRE ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Sputum Trace Metals Are Biomarkers of Inflammatory and Suppurative Lung Disease )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Andrew+P%2E+Greening%22">Andrew P. Greening</searchLink><br /><searchLink fieldCode="AR" term="%22Donald+Noble%22">Donald Noble</searchLink><br /><searchLink fieldCode="AR" term="%22M%2E+Imrie%22">M. Imrie</searchLink><br /><searchLink fieldCode="AR" term="%22Dennis+St%2E+J%2E+O'Reilly%22">Dennis St. J. O'Reilly</searchLink><br /><searchLink fieldCode="AR" term="%22Robert+D%2E+Gray%22">Robert D. Gray</searchLink><br /><searchLink fieldCode="AR" term="%22A%2E+Christopher+Boyd%22">A. Christopher Boyd</searchLink><br /><searchLink fieldCode="AR" term="%22David+J%2E+Porteous%22">David J. Porteous</searchLink><br /><searchLink fieldCode="AR" term="%22Andrew+Duncan%22">Andrew Duncan</searchLink><br /><searchLink fieldCode="AR" term="%22J%2E+Alastair+Innes%22">J. Alastair Innes</searchLink> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Gray, R D, Duncan, A, Noble, D, Imrie, M, O'Reilly, D S, Innes, J A, Porteous, D J, Greening, A P & Boyd, A C 2010, ' Sputum trace metals are biomarkers of inflammatory and suppurative lung disease ', Chest, vol. 137, no. 3, pp. 635-641 . https://doi.org/10.1378/chest.09-1047 )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Elsevier BV, 2010. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2010 )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Adult%22">Adult</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+and+Respiratory+Medicine%22">Pulmonary and Respiratory Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Adult+Aged+Asthma%2F*diagnosis%2Fmetabolism+Biological+Markers%2F*analysis+Bronchiectasis%2F*diagnosis%2Fmetabolism+Copper%2Fanalysis+Cystic+Fibrosis%2F*diagnosis%2Fmetabolism+Diagnosis%2C+Differential+Female+Humans+Iron%2Fanalysis+Male+Manganese%2Fanalysis+Middle+Aged+Pulmonary+Disease%2C+Chronic+Obstructive%2F*diagnosis%2Fmetabolism+Reproducibility+of+Results+Spectrum+Analysis+Sputum%2F*chemistry+Suppuration+Trace+Elements%2F*analysis+Zinc%2Fanalysis%22">Adult Aged Asthma/*diagnosis/metabolism Biological Markers/*analysis Bronchiectasis/*diagnosis/metabolism Copper/analysis Cystic Fibrosis/*diagnosis/metabolism Diagnosis, Differential Female Humans Iron/analysis Male Manganese/analysis Middle Aged Pulmonary Disease, Chronic Obstructive/*diagnosis/metabolism Reproducibility of Results Spectrum Analysis Sputum/*chemistry Suppuration Trace Elements/*analysis Zinc/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Cystic+Fibrosis%22">Cystic Fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Exacerbation%22">Exacerbation</searchLink><br /><searchLink fieldCode="DE" term="%22Iron%22">Iron</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Critical+Care+and+Intensive+Care+Medicine%22">Critical Care and Intensive Care Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Cystic+fibrosis%22">Cystic fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%2C+Differential%22">Diagnosis, Differential</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+Disease%2C+Chronic+Obstructive%22">Pulmonary Disease, Chronic Obstructive</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Aged%22">Aged</searchLink><br /><searchLink fieldCode="DE" term="%22Asthma%22">Asthma</searchLink><br /><searchLink fieldCode="DE" term="%22Manganese%22">Manganese</searchLink><br /><searchLink fieldCode="DE" term="%22COPD%22">COPD</searchLink><br /><searchLink fieldCode="DE" term="%22Suppuration%22">Suppuration</searchLink><br /><searchLink fieldCode="DE" term="%22Bronchiectasis%22">Bronchiectasis</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22Spectrum+Analysis%22">Spectrum Analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+disease%22">Respiratory disease</searchLink><br /><searchLink fieldCode="DE" term="%22Sputum%22">Sputum</searchLink><br /><searchLink fieldCode="DE" term="%22Reproducibility+of+Results%22">Reproducibility of Results</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+Aged%22">Middle Aged</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Trace+Elements%22">Trace Elements</searchLink><br /><searchLink fieldCode="DE" term="%22respiratory+tract+diseases%22">respiratory tract diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Zinc%22">Zinc</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Esymptom%22">medicine.symptom</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiology+and+Cardiovascular+Medicine%22">Cardiology and Cardiovascular Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Copper%22">Copper</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Background: Induced sputum cytology and protein biomarkers can be used to assess airways infl ammation. Increases in sputum iron have been described in infl ammatory lung disease. We hypothesized that other sputum metals may be affected by airways infl ammation and investigated their potential value as biomarkers. Methods: Sputum was obtained from 20 healthy control subjects and from patients with infl ammatory pulmonary diseases (23 with cystic fi brosis [CF], 16 with bronchiectasis, 17 with asthma, and 23 with COPD), and iron, zinc, manganese, and copper were measured. Fourteen patients with CF were also studied through an exacerbation cycle. Results: Sputum zinc and iron were elevated in CF and non-CF bronchiectasis vs controls ( P , .001, zinc; P , .01 iron). Manganese was elevated in asthma ( P , .01) and bronchiectasis ( P , .05) vs controls. Copper was elevated in CF vs controls ( P , .05). Zinc decreased ( P , .01) following treatment of CF exacerbation. In subjects with CF zinc levels correlated with other biomarkers. Conclusions: These results suggest a relationship of high concentrations of total zinc and iron with airways infl ammation in CF and non-CF bronchiectasis, with longitudinal changes being observed in CF. Further work is required to elucidate potential infl ammatory mechanisms related to these observations. CHEST 2010; 137(3):635–641 )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => application/pdf )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 0012-3692 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1378/chest.09-1047 )
Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f73e8d586ccb5edf44db66efd50baf" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f73e8d586ccb5edf44db66efd50baf</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1378/chest.09-1047" linkWindow="_blank">https://doi.org/10.1378/chest.09-1047</link> )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....51f73e8d586ccb5edf44db66efd50baf )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.1378/chest.09-1047 ) ) [Languages] => Array ( [0] => Array ( [Text] => Undetermined ) ) [PhysicalDescription] => Array ( [Pagination] => Array ( [PageCount] => 7 [StartPage] => 635 ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => Adult [Type] => general ) [1] => Array ( [SubjectFull] => Male [Type] => general ) [2] => Array ( [SubjectFull] => Pulmonary and Respiratory Medicine [Type] => general ) [3] => Array ( [SubjectFull] => Adult Aged Asthma/*diagnosis/metabolism Biological Markers/*analysis Bronchiectasis/*diagnosis/metabolism Copper/analysis Cystic Fibrosis/*diagnosis/metabolism Diagnosis, Differential Female Humans Iron/analysis Male Manganese/analysis Middle Aged Pulmonary Disease, Chronic Obstructive/*diagnosis/metabolism Reproducibility of Results Spectrum Analysis Sputum/*chemistry Suppuration Trace Elements/*analysis Zinc/analysis [Type] => general ) [4] => Array ( [SubjectFull] => Cystic Fibrosis [Type] => general ) [5] => Array ( [SubjectFull] => Exacerbation [Type] => general ) [6] => Array ( [SubjectFull] => Iron [Type] => general ) [7] => Array ( [SubjectFull] => Inflammation [Type] => general ) [8] => Array ( [SubjectFull] => Critical Care and Intensive Care Medicine [Type] => general ) [9] => Array ( [SubjectFull] => Cystic fibrosis [Type] => general ) [10] => Array ( [SubjectFull] => Diagnosis, Differential [Type] => general ) [11] => Array ( [SubjectFull] => Pulmonary Disease, Chronic Obstructive [Type] => general ) [12] => Array ( [SubjectFull] => Humans [Type] => general ) [13] => Array ( [SubjectFull] => Medicine [Type] => general ) [14] => Array ( [SubjectFull] => Aged [Type] => general ) [15] => Array ( [SubjectFull] => Asthma [Type] => general ) [16] => Array ( [SubjectFull] => Manganese [Type] => general ) [17] => Array ( [SubjectFull] => COPD [Type] => general ) [18] => Array ( [SubjectFull] => Suppuration [Type] => general ) [19] => Array ( [SubjectFull] => Bronchiectasis [Type] => general ) [20] => Array ( [SubjectFull] => business.industry [Type] => general ) [21] => Array ( [SubjectFull] => Spectrum Analysis [Type] => general ) [22] => Array ( [SubjectFull] => Respiratory disease [Type] => general ) [23] => Array ( [SubjectFull] => Sputum [Type] => general ) [24] => Array ( [SubjectFull] => Reproducibility of Results [Type] => general ) [25] => Array ( [SubjectFull] => Middle Aged [Type] => general ) [26] => Array ( [SubjectFull] => medicine.disease [Type] => general ) [27] => Array ( [SubjectFull] => Trace Elements [Type] => general ) [28] => Array ( [SubjectFull] => respiratory tract diseases [Type] => general ) [29] => Array ( [SubjectFull] => Zinc [Type] => general ) [30] => Array ( [SubjectFull] => Immunology [Type] => general ) [31] => Array ( [SubjectFull] => Female [Type] => general ) [32] => Array ( [SubjectFull] => medicine.symptom [Type] => general ) [33] => Array ( [SubjectFull] => Cardiology and Cardiovascular Medicine [Type] => general ) [34] => Array ( [SubjectFull] => business [Type] => general ) [35] => Array ( [SubjectFull] => Biomarkers [Type] => general ) [36] => Array ( [SubjectFull] => Copper [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Sputum Trace Metals Are Biomarkers of Inflammatory and Suppurative Lung Disease [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Andrew P. Greening ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Donald Noble ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => M. Imrie ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Dennis St. J. O'Reilly ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Robert D. Gray ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => A. Christopher Boyd ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => David J. Porteous ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Andrew Duncan ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => J. Alastair Innes ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 03 [Type] => published [Y] => 2010 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 00123692 ) [1] => Array ( [Type] => issn-locals [Value] => edsair ) [2] => Array ( [Type] => issn-locals [Value] => edsairFT ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 137 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Chest [Type] => main ) ) ) ) ) ) )
IllustrationInfo