Application of radioreceptor assays for systematic toxicological analysis
| العنوان: | Application of radioreceptor assays for systematic toxicological analysis |
|---|---|
| المؤلفون: | R.A. de Zeeuw, J.P. Franke, Antoine C. G. Egberts, Kees Ensing, I.J Bosman |
| المصدر: | Journal of Pharmaceutical and Biomedical Analysis, 12(1), 59-63. ELSEVIER SCIENCE BV |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | BENZODIAZEPINE, Radioreceptor Assays, Clinical Biochemistry, Histamine Antagonists, Pharmaceutical Science, Pharmacology, THERAPEUTIC DRUG MONITORING, Toxicology, Biological fluid, Analytical Chemistry, ANTICHOLINERGIC, Benzodiazepines, Radioligand Assay, RADIORECEPTOR ASSAYS, Drug Discovery, Healthy volunteers, medicine, Humans, Spectroscopy, Binding Sites, medicine.diagnostic_test, IDENTIFICATION, Chemistry, Parasympatholytics, Reproducibility of Results, ANTIHISTAMINIC, SCREENING, Histamine H2 Antagonists, Therapeutic drug monitoring, Histamine H1 Antagonists, SYSTEMATIC TOXICOLOGICAL ANALYSIS |
| الوصف: | In this paper the applicability ot radioreceptor assays tor systematic toxicological analysis will be evaluated on a theoretical basis as well as on the basis of the outcomes of the analysis of a large number of urine samples collected after administration of a selected number of drugs to healthy volunteers and patients. Many drugs and other substances of toxicological relevance exert their action through an interaction with one or more receptor (sub)types. Whether the number of persons are using particular drugs intentionally of unintentionally, radioreceptor assays can be a useful tool for systematic toxicological analysis in that they can be applied to the identification ot entire pharmacological classes of substances as well as pharmacologically active metabolites. In part 1 of this paper detailed procedures for radioreceptor assays for benzodiazepines, anticholinergics and antihistaminics have Deen described in detail in order to illustrate not only the potentials but also the limitations of assay conditions. Fifteen drugs were administered to patients and volunteers and urine samples were collected and determined with the three radioreceptor assays. The results ot this study underline the theoretical applicability ot receptor assays in systematic toxicological analysis though sample pretreatment procedures may contribute to an improvement in sensitivity and applicability to other biofluids. |
| اللغة: | English |
| تدمد: | 0731-7085 |
| DOI: | 10.1016/0731-7085(94)80010-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0ad80ad97fc97facba3a20ba77880f https://doi.org/10.1016/0731-7085(94)80010-3 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4e0ad80ad97fc97facba3a20ba77880f |
| قاعدة البيانات: | OpenAIRE |
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