Efficacious treatment of non-dermatophyte mould onychomycosis with topical amphotericin B
| العنوان: | Efficacious treatment of non-dermatophyte mould onychomycosis with topical amphotericin B |
|---|---|
| المؤلفون: | Michel Monod, Florence Baudraz-Rosselet, Olympia Bontems, Phillip Spring, Marina Fratti, Maxime Vernez, Massimo Lurati |
| المصدر: | Dermatology (Basel, Switzerland). 223(4) |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Antifungal Agents, Itraconazole, Dermatology, Hand Dermatoses, Aspergillosis, medicine.disease_cause, Amphotericin B, Onychomycosis, medicine, Humans, Mycosis, Aged, business.industry, Middle Aged, medicine.disease, Surgery, Acremonium, medicine.anatomical_structure, Treatment Outcome, Nail disease, Fusariosis, Nail (anatomy), Dermatophyte, Terbinafine, Female, business, medicine.drug |
| الوصف: | Background: Dermatophytes are the main cause of onychomycosis, but various non-dermatophyte moulds (NDMs) are often the infectious agents in abnormal nails. In particular, Fusarium spp. and other NDMs are mostly insensitive to standard onychomycosis treatment with topical agents as well as with oral terbinafine and itraconazole. Objective: The aim of this work is to report the efficacy of a topical amphotericin B solution on NDM onychomycosis in a series of 8 patients resistant to multiple conventional topical and systemic treatments. Methods: Treatment consisted in the application of an optimized amphotericin B solution once daily to the affected nails and surrounding tissue. No mechanical debridement or medications were allowed except for trimming excessively long nails or in some cases occasionally applying urea-based cream to soften thickened nail plates. Results: Onychomycosis was clinically cured in all patients after a 12-month treatment. Mycological cure was obtained in all but 1 patient. Conclusions: Topical amphotericin B is an efficacious, safe, cheap and easy-to-apply treatment which should be considered as first-line therapy for NDM onychomycosis. |
| تدمد: | 1421-9832 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4daa30de51c7193428dab686cee75ab8 https://pubmed.ncbi.nlm.nih.gov/22236569 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4daa30de51c7193428dab686cee75ab8 |
| قاعدة البيانات: | OpenAIRE |
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