The effect of bladder diverticula on bladder function: An experimental study in rabbits
| العنوان: | The effect of bladder diverticula on bladder function: An experimental study in rabbits |
|---|---|
| المؤلفون: | Özgür Kuzdan, Seyithan Özaydın, Mehmet Yazıcı, Serdar Sander, İpek Özaydın, Cemile Başdaş, Süleyman Çelebi |
| المصدر: | Journal of Pediatric Surgery. 51:1538-1542 |
| بيانات النشر: | Elsevier BV, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Urinary Bladder, Dysfunctional voiding, 030232 urology & nephrology, Urology, Reference range, urologic and male genital diseases, Random Allocation, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Bladder diverticulum, Urinary Bladder Calculi, 030219 obstetrics & reproductive medicine, Urinary bladder, business.industry, Sham surgery, General Medicine, female genital diseases and pregnancy complications, Surgery, Compliance (physiology), Diverticulum, Urodynamics, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Rabbits, Multiple bladder diverticula, Bladder function, business |
| الوصف: | This study aims to evaluate the effect of bladder diverticula (BD) on bladder function using a rabbit model, based on urodynamic findings.A total of 32 New Zealand white rabbits were randomly assigned to four groups: (1) sham surgery; (2) a single, 1-cm-diameter BD; (3) a single, large, 3-cm-diameter BD; and (4) four (multi) 1-cm-diameter BD. Urodynamic evaluations were performed preoperatively, and 1week and 1month postoperatively, to measure the postmicturition residual (PMR), maximum bladder capacity (MBC), filling and voiding detrusor pressure (Pdet), compliance, and unstable detrusor contractions. At the end of the study, the animals were sacrificed and assessed for pathologic evaluation and stone formation.In groups 3 and 4, the rabbits all had PMR. At 30days postsurgery, the MBC was found to be 28% and 31% lower than the reference range in groups 3 and 4 and compliance was decreased (p0.05). Further, the filling Pdet was significantly higher for large and multiple BD than in the 1-cm diverticula or sham groups (6.33±1.73, 4±1.26, p=0.0001). Groups 3 (62%) and 4 (50%) had unstable detrusor contractions. There was also a muscular/collagen ratio increase in the large and multiple BD groups. Four rabbits in the large group and one rabbit in the multiple BD group exhibited stone formation.Large or multiple BD can alter bladder storage and emptying, and can decrease the capacity of the bladder and reduce its elasticity. Large or multiple bladder diverticula can lead to involuntary contractions, causing dysfunctional voiding. |
| تدمد: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2016.02.087 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d61df2e76d12cafca6d5ccaa50d776f https://doi.org/10.1016/j.jpedsurg.2016.02.087 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4d61df2e76d12cafca6d5ccaa50d776f |
| قاعدة البيانات: | OpenAIRE |
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