UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression
| العنوان: | UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression |
|---|---|
| المؤلفون: | Lauren E. Howard, Skyla T. Carney, Stephen J. Freedland, Jiaoti Huang, Delores J. Grant, Adriana C. Vidal, Amanda De Hoedt, Emily Wiggins, Clara E. Magyar, Zinan Chen, Jill Squires |
| المصدر: | BMC cancer, vol 17, iss 1 BMC Cancer BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017) |
| بيانات النشر: | eScholarship, University of California, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, Cancer Research, Pathology, Aging, medicine.medical_treatment, Gene Expression, Prostate cancer, 0302 clinical medicine, Prostate, Recurrence, Glucuronosyltransferase, Testosterone, Cancer, Prostatectomy, breakpoint cluster region, Dihydrotestosterone, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, UGT2B17, Immunohistochemistry, 3. Good health, Isoenzymes, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Disease Progression, Public Health and Health Services, UDP-glucuronosyltransferases, Research Article, medicine.drug, Biochemical recurrence, Urologic Diseases, medicine.medical_specialty, Oncology and Carcinogenesis, lcsh:RC254-282, 03 medical and health sciences, Clinical Research, Internal medicine, Genetics, medicine, Humans, Oncology & Carcinogenesis, Proportional Hazards Models, Retrospective Studies, Aged, business.industry, Proportional hazards model, Prostatic Neoplasms, medicine.disease, 030104 developmental biology, business, Biomarkers, Follow-Up Studies |
| الوصف: | BackgroundUridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15, UGT2B17, and UGT2B28 enzymes has not been evaluated in prostate tissue samples from hormone therapy-naïve patients.MethodsWe determined the expression of UGT2B15, UGT2B17, and UGT2B28 enzymes in 190 prostate tissue samples from surgical specimens of a multiethnic cohort of patients undergoing radical prostatectomy at the Durham Veterans Affairs Medical Center. The association between each protein's percent positive and H-score, a weighted score of staining intensity, and the risk of biochemical recurrence (BCR) was tested using separate Cox proportional hazards models. In an exploratory analysis, UGT2B17 total positive and H-score were divided at the median and we tested the association between UGT2B17 group and risk of BCR.ResultsThe median follow-up for all patients was 118months (IQR: 85-144). Of 190, 83 (44%) patients developed BCR. We found no association between UGT2B15 or UGT2B28 and risk of BCR. However, there was a trend for an association between UGT2B17 and BCR (HR=1.01, 95% CI 1.00-1.02, p=0.11), though not statistically significant. Upon further investigation, we found that patients with UGT2B17 higher levels of expression had a significant increased risk of BCR on univariable analysis (HR=1.57, 95% CI 1.02-2.43, p=0.041), although this association was attenuated in the multivariable model (HR=1.50, 95% CI 0.94-2.40, p=0.088).ConclusionsOur findings suggest that UGT2B17 overexpression may be associated with a significant increased risk of BCR. These results are consistent with previous reports which showed UGT2B17 significantly expressed in advanced prostate cancer including prostate tumor metastases. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f8f997a5ed8def9316395dba0bcd44 https://escholarship.org/uc/item/3pf6t1sk |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....48f8f997a5ed8def9316395dba0bcd44 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |