Tamper-Proof Time–Temperature Indicator for Inspecting Ultracold Supply Chain
| العنوان: | Tamper-Proof Time–Temperature Indicator for Inspecting Ultracold Supply Chain |
|---|---|
| المؤلفون: | Lam Tan Hao, Minkyung Lee, Jun Mo Koo, Sung Yeon Hwang, Dongyeop X. Oh, Jeyoung Park, Hyeonyeol Jeon |
| المصدر: | ACS Omega ACS Omega, Vol 6, Iss 12, Pp 8598-8604 (2021) |
| بيانات النشر: | American Chemical Society, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Messenger ribonucleic acid, 2019-20 coronavirus outbreak, Time temperature indicator, Coronavirus disease 2019 (COVID-19), business.industry, General Chemical Engineering, Supply chain, General Chemistry, Temperature a, Article, Chemistry, Environmental science, Process engineering, business, Monitoring tool, QD1-999, Tamper resistance |
| الوصف: | In the precarious situation caused by the COVID-19 pandemic, the use of messenger ribonucleic acid (mRNA) vaccines is promising for prevention against the infection However, this type of vaccine has not been effectively commercialized because it needs to be stored and transported at ultracold conditions mRNA vaccines exposed to undesired temperatures may not show any visible changes but can deteriorate and cause negative effects Consumers' demand for vaccine authenticity requires logistics to develop a robust monitoring tool to ensure the integrity of ultracold supply chain from manufacturing until vaccination Here, we report a time-temperature indicator (TTI) that can detect a relatively small change in temperature within subzero ranges, for example, from -70 to -60 degreeC, which cannot be achieved by current TTIs operating at room temperature A dyed noneutectic ethylene glycol/water mixture that melts near the mRNA conservation temperature (-69 degreeC) diffuses into a white absorbent and leaves a colored trace In addition, the heterogeneous ice particles in the noneutectic mobile phase can prevent absorption during short-term exposure to room temperature Therefore, the proposed TTI will not record inevitable "meaningless" short-term exposure to room temperature during the cold supply chain but monitor the "meaningful" relatively long-term exposure above -60 degreeC These findings help facilitate the safe distribution of the COVID-19 mRNA vaccines |
| اللغة: | English |
| تدمد: | 2470-1343 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480ca1b3e13126464e85e0aa06a0a106 http://europepmc.org/articles/PMC8015080 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....480ca1b3e13126464e85e0aa06a0a106 |
| قاعدة البيانات: | OpenAIRE |
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