Molecular Effects of Silver Nanoparticles on Monogenean Parasites: Lessons from Caenorhabditis elegans
العنوان: | Molecular Effects of Silver Nanoparticles on Monogenean Parasites: Lessons from Caenorhabditis elegans |
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المؤلفون: | Humberto H Lara, Cristina Chávez-Sánchez, Jorge Ramírez-Salcedo, Alejandra García-Gasca, Emma J. Fajer-Ávila, Citlalic A. Pimentel-Acosta, Francisco Neptalí Morales-Serna |
المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 5889, p 5889 (2020) International Journal of Molecular Sciences Volume 21 Issue 16 |
بيانات النشر: | MDPI AG, 2020. |
سنة النشر: | 2020 |
مصطلحات موضوعية: | 0301 basic medicine, Cell signaling, Programmed cell death, silver nanoparticles, DNA damage, 010501 environmental sciences, Caenorhabditis elegans, 01 natural sciences, Catalysis, Silver nanoparticle, Cichlidogyrus, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, Gene expression, Physical and Theoretical Chemistry, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, 0105 earth and related environmental sciences, biology, Chemistry, Microarray analysis techniques, Organic Chemistry, monogenean parasites, General Medicine, Viral tegument, biology.organism_classification, Computer Science Applications, Cell biology, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, gene expression, microarray analysis |
الوصف: | The mechanisms of action of silver nanoparticles (AgNPs) in monogenean parasites of the genus Cichlidogyrus were investigated through a microarray hybridization approach using genomic information from the nematode Caenorhabditis elegans. The effects of two concentrations of AgNPs were explored, low (6 µ g/L Ag) and high (36 µ g/L Ag). Microarray analysis revealed that both concentrations of AgNPs activated similar biological processes, although by different mechanisms. Expression profiles included genes involved in detoxification, neurotoxicity, modulation of cell signaling, reproduction, embryonic development, and tegument organization as the main biological processes dysregulated by AgNPs. Two important processes (DNA damage and cell death) were mostly activated in parasites exposed to the lower concentration of AgNPs. To our knowledge, this is the first study providing information on the sub-cellular and molecular effects of exposure to AgNPs in metazoan parasites of fish. |
وصف الملف: | application/pdf |
اللغة: | English |
تدمد: | 1661-6596 1422-0067 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44dbd39419fffe2d7168a61258f1f7c8 https://www.mdpi.com/1422-0067/21/16/5889 |
Rights: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....44dbd39419fffe2d7168a61258f1f7c8 |
قاعدة البيانات: | OpenAIRE |
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