Impact of mass drug administration campaigns depends on interaction with seasonal human movement
| العنوان: | Impact of mass drug administration campaigns depends on interaction with seasonal human movement |
|---|---|
| المؤلفون: | Amelia Bertozzi-Villa, Philip A. Eckhoff, Edward Allen Wenger, Jaline Gerardin |
| المصدر: | International Health |
| بيانات النشر: | Oxford University Press, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Health (social science), Human Migration, 030231 tropical medicine, Biology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Malaria transmission, law, Dry season, Malaria Vaccines, medicine, Humans, 030212 general & internal medicine, Mass drug administration, skin and connective tissue diseases, Mathematical modelling, Public Health, Environmental and Occupational Health, General Medicine, Original Articles, Models, Theoretical, medicine.disease, Malaria, Transmission (mechanics), Seasonal human movement, Seasons, Demography, Program Evaluation |
| الوصف: | Background Mass drug administration (MDA) is a control and elimination tool for treating infectious diseases. For malaria, it is widely accepted that conducting MDA during the dry season results in the best outcomes. However, seasonal movement of populations into and out of MDA target areas is common in many places and could potentially fundamentally limit the ability of MDA campaigns to achieve elimination. Methods A mathematical model was used to simulate malaria transmission in two villages connected to a high-risk area into and out of which 10% of villagers traveled seasonally. MDA was given only in the villages. Prevalence reduction under various possible timings of MDA and seasonal travel was predicted. Results MDA is most successful when distributed outside the traveling season and during the village low-transmission season. MDA is least successful when distributed during the traveling season and when traveling overlaps with the peak transmission season in the high-risk area. Mistiming MDA relative to seasonal travel resulted in much poorer outcomes than mistiming MDA relative to the peak transmission season within the villages. Conclusions Seasonal movement patterns of high-risk groups should be taken into consideration when selecting the optimum timing of MDA campaigns. |
| اللغة: | English |
| تدمد: | 1876-3405 1876-3413 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409cfe0efd6f4eea8c26782142c757ea http://europepmc.org/articles/PMC6031018 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....409cfe0efd6f4eea8c26782142c757ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18763405 18763413 |
|---|