Characterization of a neuropeptide F receptor in the tsetse fly, Glossina morsitans morsitans
| العنوان: | Characterization of a neuropeptide F receptor in the tsetse fly, Glossina morsitans morsitans |
|---|---|
| المؤلفون: | Liesbeth Van Rompay, Isabel Beets, Sven Zels, Matthias B. Van Hiel, Liliane Schoofs, Jelle Caers, Katleen Peymen, Jan Van Den Abbeele |
| المصدر: | Journal of Insect Physiology. :105-111 |
| بيانات النشر: | Elsevier BV, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Receptors, Neuropeptide, 0301 basic medicine, Neuropeptide F, PREDICTION, Physiology, Gene Expression, Insect, Synaptic Transmission, 0302 clinical medicine, PCR DATA, PEST-CONTROL, Cloning, Molecular, Receptor, media_common, Neurotransmitter Agents, Tsetse fly, Y-LIKE SYSTEM, Neuropeptide Y receptor, SCHISTOCERCA-GREGARIA, Cell biology, Glossina morsitans morsitans, PROTEIN-COUPLED RECEPTOR, BOMBYX-MORI, Larva, Insect Proteins, Female, SIGNALING PATHWAY, Life Sciences & Biomedicine, medicine.medical_specialty, DNA, Complementary, Tsetse Flies, media_common.quotation_subject, DESERT LOCUST, Neuropeptide, Biology, 03 medical and health sciences, Internal medicine, medicine, Animals, G protein-coupled receptor, Amino Acid Sequence, Science & Technology, Base Sequence, Neuropeptides, fungi, Midgut, Feeding Behavior, biology.organism_classification, 030104 developmental biology, Endocrinology, DROSOPHILA-MELANOGASTER, Insect Science, Trypanosoma, Entomology, Zoology, 030217 neurology & neurosurgery |
| الوصف: | Neuropeptides related to mammalian neuropeptide Y (NPY) and insect neuropeptide F (NPF) are conserved throughout Metazoa and intimately involved in a wide range of biological processes. In insects NPF is involved in regulating feeding, learning, stress and reproductive behavior. Here we identified and characterized an NPF receptor of the tsetse fly, Glossina morsitans morsitans, the sole transmitter of Trypanosoma parasites causing sleeping sickness. We isolated cDNA sequences encoding tsetse NPF (Glomo-NPF) and its receptor (Glomo-NPFR), and examined their spatial and temporal expression patterns using quantitative PCR. In tsetse flies, npfr transcripts are expressed throughout development and most abundantly in the central nervous system, whereas low expression is found in the flight muscles and posterior midgut. Expression of npf, by contrast, shows low transcript levels during development but is strongly expressed in the posterior midgut and brain of adult flies. Expression of Glomo-npf and its receptor in the brain and digestive system suggests that NPF may have conserved neuromodulatory or hormonal functions in tsetse flies, such as in the regulation of feeding behavior. Cell-based activity studies of the Glomo-NPFR showed that Glomo-NPF activates the receptor up to nanomolar concentrations. The molecular data of Glomo-NPF and Glomo-NPFR paves the way for further investigation of its functions in tsetse flies. senior author publication ispartof: Journal of Insect Physiology vol:93 pages:105-111 ispartof: location:England status: published |
| وصف الملف: | Print-Electronic |
| تدمد: | 0022-1910 |
| DOI: | 10.1016/j.jinsphys.2016.09.013 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1a2b2e23e315acc261e547220fd6a3 https://doi.org/10.1016/j.jinsphys.2016.09.013 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3c1a2b2e23e315acc261e547220fd6a3 |
| قاعدة البيانات: | OpenAIRE |
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