Roles of membrane transporters: connecting the dots from sequence to phenotype
| العنوان: | Roles of membrane transporters: connecting the dots from sequence to phenotype |
|---|---|
| المؤلفون: | Matthew Gilliham, Stefanie Wege, Rakesh David, Stephen D. Tyerman, Caitlin S. Byrt |
| المصدر: | Ann Bot |
| بيانات النشر: | Oxford University Press, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 2. Zero hunger, 0106 biological sciences, 0301 basic medicine, Invited Review, Systems biology, Membrane Transport Proteins, Membrane Transporters, Transporter, Plant Science, Computational biology, Biology, Plants, 01 natural sciences, Phenotype, Transport protein, 03 medical and health sciences, 030104 developmental biology, Single amino acid, Amino Acid Sequence, Function (biology), Plant Physiological Phenomena, 010606 plant biology & botany, Sequence (medicine) |
| الوصف: | BackgroundPlant membrane transporters are involved in diverse cellular processes underpinning plant physiology, such as nutrient acquisition, hormone movement, resource allocation, exclusion or sequestration of various solutes from cells and tissues, and environmental and developmental signalling. A comprehensive characterization of transporter function is therefore key to understanding and improving plant performance.Scope and ConclusionsIn this review, we focus on the complexities involved in characterizing transporter function and the impact that this has on current genomic annotations. Specific examples are provided that demonstrate why sequence homology alone cannot be relied upon to annotate and classify transporter function, and to show how even single amino acid residue variations can influence transporter activity and specificity. Misleading nomenclature of transporters is often a source of confusion in transporter characterization, especially for people new to or outside the field. Here, to aid researchers dealing with interpretation of large data sets that include transporter proteins, we provide examples of transporters that have been assigned names that misrepresent their cellular functions. Finally, we discuss the challenges in connecting transporter function at the molecular level with physiological data, and propose a solution through the creation of new databases. Further fundamental in-depth research on specific transport (and other) proteins is still required; without it, significant deficiencies in large-scale data sets and systems biology approaches will persist. Reliable characterization of transporter function requires integration of data at multiple levels, from amino acid residue sequence annotation to more in-depth biochemical, structural and physiological studies. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bef9e25740aeed81f97e9bcf85e423 https://europepmc.org/articles/PMC6758574/ |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....36bef9e25740aeed81f97e9bcf85e423 |
| قاعدة البيانات: | OpenAIRE |
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