Randomized study of granulocyte colony stimulating factor for childhood B-cell non-Hodgkin lymphoma: a report from the Japanese pediatric leukemia/lymphoma study group B-NHL03 study
| العنوان: | Randomized study of granulocyte colony stimulating factor for childhood B-cell non-Hodgkin lymphoma: a report from the Japanese pediatric leukemia/lymphoma study group B-NHL03 study |
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| المؤلفون: | Reiji Fukano, Akiko Saito, Tetsuya Mori, Masahito Tsurusawa, Atsuko Nakazawa, Tetsuo Mitsui, Shosuke Sunami, Yoshihiro Komada, Tomoyuki Watanabe, Yoshiyuki Kosaka, Ryoji Kobayashi, Fumiko Tanaka, Naoto Fujita, Hiroko Inada, Masahiro Sekimizu, Katsuyoshi Koh, Keizo Horibe, Masahiko Gosho |
| المصدر: | Leukemia & Lymphoma. 57:1657-1664 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Cancer Research, Pediatrics, medicine.medical_specialty, Lymphoma, B-Cell, Neutropenia, Adolescent, medicine.medical_treatment, 030204 cardiovascular system & hematology, Infections, Chemoprevention, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Granulocyte Colony-Stimulating Factor, medicine, Humans, Neoplasm Metastasis, Child, Stomatitis, Neoplasm Staging, Chemotherapy, business.industry, Health Care Costs, Hematology, medicine.disease, Thrombocytopenia, Lymphoma, Granulocyte colony-stimulating factor, Hospitalization, Lenograstim, Treatment Outcome, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, B-Cell Non-Hodgkin Lymphoma, Female, business, Febrile neutropenia |
| الوصف: | The objective of this study was to assess the impact of the primary prophylaxis of granulocyte colony-stimulating factor (G-CSF) in the management of childhood B-cell non-Hodgkin lymphoma (B-NHL). Patients with advanced-stage mature B-NHL were randomized to receive prophylactic G-CSF (G-CSF+) or not receive G-CSF (G-CSF−) based on protocols of the B-NHL03 study. The G-CSF group received 5 μg/kg/d Lenograstim from day 2 after each course of six chemotherapy courses. Fifty-eight patients were assessable, 29 G-CSF + and 29 G-CSF−. G-CSF + patients showed a positive impact on the meantime to neutrophil recovery and hospital stay. On the other hand, they had no impact in the incidences of febrile neutropenia, serious infections, stomatitis and total cost. Our study showed that administration of prophylactic G-CSF through all six chemotherapy courses for childhood B-NHL showed no clinical and economic benefits for the management of childhood B-NHL treatment. |
| تدمد: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428194.2015.1106534 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3444a2c68c6556cafcd0490971495019 https://doi.org/10.3109/10428194.2015.1106534 |
| رقم الانضمام: | edsair.doi.dedup.....3444a2c68c6556cafcd0490971495019 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10292403 10428194 |
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| DOI: | 10.3109/10428194.2015.1106534 |