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Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression

التفاصيل البيبلوغرافية
العنوان: Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression
المؤلفون: Jan A. Åkervall, Rob Michalides, Hiroyuki Mineta, Åke Borg, Alfons Balm, Johan P. Wennerberg, Barbara Loftus, Yuesheng Jin, Fredrik Mertens, Michael R. Dictor
المساهمون: Other departments
المصدر: Cancer, 79(2), 380-389. John Wiley and Sons Inc.
بيانات النشر: Wiley, 1997.
سنة النشر: 1997
مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, Cyclin D, Cyclin B, medicine.disease_cause, Cyclin D1, Cyclins, medicine, Humans, Aged, Aged, 80 and over, Chromosome Aberrations, Gene Rearrangement, Oncogene Proteins, biology, Chromosomes, Human, Pair 11, Gene Amplification, Cytogenetics, Cancer, Gene rearrangement, Middle Aged, Prognosis, medicine.disease, Neoplasm Proteins, Phenotype, Oncology, Epidermoid carcinoma, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Cancer research, biology.protein, Female, Carcinogenesis
الوصف: BACKGROUND Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck (SCCHN). The oncogene CCND1 is located at 11q13 and encodes cyclin D1, a cell cycle-regulating protein. The authors investigated the clinical relevance and associations between amplification and overexpression of cyclin D1 and 11q13 rearrangements. METHODS The study involved two series of patients. In Series 1, overexpression of cyclin D1 and 11q13 rearrangements, assessed by immunohistochemistry and cytogenetics, respectively, were compared with clinical data in 75 patients with SCCHN. Patients were monitored for at least 18 months or until death. In another 23 patients (Series 2), the authors investigated the association between DNA amplification (by slot blot hybridization), overexpression of cyclin D1, and cytogenetics. RESULTS In Series 1, 9 of 75 tumors (12%) had 11q13 aberrations, 6 of which manifested elevated expression of cyclin D1. Patients with tumors strongly positive for cyclin D1 (n = 9) and those with tumors showing 11q13 rearrangements had poorer survival (P = 0.047 and 0.005, respectively). However, the correlation between these two variables was weak (P = 0.12). In Series 2, 17 of 23 tumors (74%) showed elevated cyclin D1 protein expression, and 6 of these showed gene amplification as well. Of these six, only one revealed 11q13 rearrangements. CONCLUSIONS Overexpression of cyclin D1 and 11q13 rearrangements are independent prognostic factors for SCCHN. In general, DNA amplification results in overexpression of cyclin D1, but additional genetic mechanisms are involved in the deregulation. Furthermore, oncogenes at 11q13 besides CCND1 may be involved in the tumorigenesis. Cancer 1997; 79:380-9. © 1997 American Cancer Society.
تدمد: 1097-0142
0008-543X
DOI: 10.1002/(sici)1097-0142(19970115)79:2<380::aid-cncr22>3.0.co;2-w
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9d374710051a338ea6832193d975bf
https://doi.org/10.1002/(sici)1097-0142(19970115)79:2<380::aid-cncr22>3.0.co;2-w
Rights: RESTRICTED
رقم الانضمام: edsair.doi.dedup.....2f9d374710051a338ea6832193d975bf
قاعدة البيانات: OpenAIRE
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