C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators
| العنوان: | C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators |
|---|---|
| المؤلفون: | Epole N. Ntungwe, Sofija Jovanović Stojanov, Noélia M. Duarte, Nuno R. Candeias, Ana M. Díaz-Lanza, Máté Vágvölgyi, Attila Hunyadi, Milica Pešić, Patrícia Rijo |
| المساهمون: | Tampere University, Materials Science and Environmental Engineering |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | 216 Materials engineering, Organic Chemistry, Drug Discovery, 215 Chemical engineering, Biochemistry |
| الوصف: | In this study, a bioguided fractionation of Plectranthus mutabilis extract was performed by chromatographic methods. It yielded one new nor-abietane diterpene, mutabilol (1), and three known abietanes, coleon-U-quinone (2), 8α,9α-epoxycoleon-U-quinone (3), and coleon U (4). The abietane diterpenoid 5 was also tentatively identified using HPLC-MS/MS. Moreover, the extract profile and quantification of each isolated compound were determined by HPLC-DAD. Compound 4 was the major compound in the extract. Compounds 2-4 were found to be selective toward cancer cell lines and were able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells at longer exposure of 72 h and consequently revert doxorubicin (DOX) resistance in subsequent combined treatment. None of the compounds influenced the P-gp expression in NCI-H460/R cells, while the extract significantly increased it. acceptedVersion |
| وصف الملف: | fulltext |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e74bc906e14fba8fe1f50c67f5edf01 https://trepo.tuni.fi/handle/10024/146379 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2e74bc906e14fba8fe1f50c67f5edf01 |
| قاعدة البيانات: | OpenAIRE |
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