CCND1 G870A polymorphism and colorectal cancer risk: An updated meta-analysis
| العنوان: | CCND1 G870A polymorphism and colorectal cancer risk: An updated meta-analysis |
|---|---|
| المؤلفون: | Yu‑Ming Niu, Xiao‑Bing Ni, Xiao‑Ming Xu, Gong‑Li Yang, Ming Shen, Zhi‑Guo Luo |
| المصدر: | Molecular and Clinical Oncology. 4:1078-1084 |
| بيانات النشر: | Spandidos Publications, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, medicine.medical_specialty, Colorectal cancer, business.industry, Articles, Publication bias, Odds ratio, Bioinformatics, medicine.disease, Gastroenterology, Confidence interval, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Meta-analysis, Internal medicine, Epidemiology, Genetic model, medicine, business, Genotyping |
| الوصف: | Molecular epidemiological studies have revealed a closer association between cyclin D1 (CCND1) polymorphism and the risk of colorectal cancer; however, the results were inconsistent. The aim of the present meta-analysis was to investigate the association between CCND1 G870A polymorphism and colorectal cancer risk. Online electronic databases (PubMed and Embase) were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between CCND1 G870A polymorphism and the risk of colorectal cancer. In addition, heterogeneity, publication bias and sensitivity analysis were performed to guarantee the statistical power. In total, 23 published case-control studies with 6,320 patients and 8,252 controls were selected. Significantly increased risks were observed in four genetic models (A vs. G: OR=1.09, 95% CI=1.00–1.18, I2=54.3%; GA vs. GG: OR=1.13, 95% CI=1.04–1.24, I2=18.2%; AA vs. GG, OR=1.17: 95% CI=1.00–1.38, I2=52.5%; GA+AA vs. GG: OR=1.14, 95% CI=1.05–1.24, I2=33.8%). Similarly, significant associations were also identified in the stratified analysis in the cancer subtype of sporadic colorectal cancer (GA vs. GG: OR=1.21, 95% CI=1.04–1.42, I2=24.1%; GA+AA vs. GG: OR=1.18, 95% CI=1.02–1.37, I2=35.0%), Caucasian population (GA vs. GG, OR=1.14, 95% CI=1.02–1.28, I2=19.8%; GA+AA vs. GG, OR=1.14, 95% CI=1.02–1.27, I2=37.5%) and other subgroups of control design and genotyping type. The present updated meta-analysis suggested that CCND1 G870A may present an increased risk for developing colorectal cancer, particularly in sporadic colorectal cancer and a Caucasian population. |
| تدمد: | 2049-9469 2049-9450 |
| DOI: | 10.3892/mco.2016.844 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4cc1508168a9d6cbf6551de5d5ffac https://doi.org/10.3892/mco.2016.844 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2e4cc1508168a9d6cbf6551de5d5ffac |
| قاعدة البيانات: | OpenAIRE |
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