Presence of serum RalA and serum p53 autoantibodies in 1833 patients with various types of cancers
| العنوان: | Presence of serum RalA and serum p53 autoantibodies in 1833 patients with various types of cancers |
|---|---|
| المؤلفون: | Masaaki Ito, Isamu Hoshino, Takaki Hiwasa, Yoko Oshima, Takashi Suzuki, Fumiaki Shiratori, Tatsuki Nanami, Akiko Kuwajima, Satoshi Yajima, Hideaki Shimada |
| المصدر: | International journal of clinical oncology. 27(1) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Lung Neoplasms, Esophageal Neoplasms, Colorectal cancer, Enzyme-Linked Immunosorbent Assay, Gastroenterology, Prostate cancer, Breast cancer, Prostate, Internal medicine, medicine, Biomarkers, Tumor, Humans, Lung cancer, Autoantibodies, business.industry, Cancer, Hematology, General Medicine, Esophageal cancer, medicine.disease, medicine.anatomical_structure, Oncology, Hepatocellular carcinoma, Surgery, ral GTP-Binding Proteins, Tumor Suppressor Protein p53, business |
| الوصف: | RalA is a member of the Ras superfamily of small GTPases. The Anti-RalA autoantibodies (s-RalA-Abs) act as tumor markers in various types of cancer and are negatively associated with the p53 autoantibodies (s-p53-Abs). This study aimed to evaluate the relationship between s-RalA-Abs and s-p53-Abs in various types of cancer. A total of 1833 cancer patients (esophageal cancer, 172; hepatocellular carcinoma, 91; lung cancer, 269; gastric cancer, 317; colon cancer, 262; breast cancer, 364; and prostate cancer, 358) and 73 healthy subjects were enrolled in the study. The levels of s-RalA-Abs and s-p53-Abs were analyzed using enzyme-linked immunosorbent assay, and the positivity rates and relations between the two autoantibodies were evaluated. The cutoff values for s-RalA abs and s-p53 abs were set as mean + 2 standard deviation and the values higher than the cutoff values were defined as positive. The titers in all cancer types were significantly higher than those in the controls (P |
| تدمد: | 1437-7772 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a383a35d9c03bfe1522cfcb07257ff5 https://pubmed.ncbi.nlm.nih.gov/34632560 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2a383a35d9c03bfe1522cfcb07257ff5 |
| قاعدة البيانات: | OpenAIRE |
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