Diversity in the Interaction of Amino Acid- and Peptide-Based Hydroxamic Acids with Some Platinum Group Metals in Solution
| العنوان: | Diversity in the Interaction of Amino Acid- and Peptide-Based Hydroxamic Acids with Some Platinum Group Metals in Solution |
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| المؤلفون: | Linda Bíró, Péter Buglyó, Etelka Farkas |
| المصدر: | Molecules, Vol 27, Iss 669, p 669 (2022) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Models, Molecular, Pharmaceutical Science, Organic chemistry, platinum group metals, metal complex solutions, Hydroxamic Acids, Ligands, Peptide Fragments, Analytical Chemistry, QD241-441, Chemistry (miscellaneous), Coordination Complexes, Drug Discovery, Molecular Medicine, amino acid derivatives, Physical and Theoretical Chemistry, Amino Acids, Chelating Agents, Platinum |
| الوصف: | Complexes that incorporate both ligand(s) and metal(s) exhibiting cytotoxic activity can especially be interesting to develop multifunctional drug molecules with desired activities. In this review, the limited number of solution results collected in our laboratory on the complexes of Pd(II) and two other platinum group metals—the half-sandwich type, [(η6-p-cym)Ru(H2O)3]2+, and [(η5-Cp*)Rh(H2O)3]2+—with hydroxamic acid derivatives of three amino acids, two imidazole analogues, and four small peptides are summarized and evaluated. Unlike the limited number of coordination sites of these metal ions (four and three for Pd(II) and the organometallic cations, respectively), the ligands discussed here offer a relatively high number of donor atoms as well as variation in their position within the ligands, resulting in a large versatility of the likely coordination modes. The review, besides presenting the solution equilibrium results, also discusses the main factors, such as (N,N) versus (O,O) chelate; size of chelate; amino-N versus imidazole-N; primary versus secondary hydroxamic function; differences between hydrolytic ability of the metal ions studied; and hydrolysis of the coordinated peptide hydroxamic acids in their Pd(II) complexes, which all determine the coordination modes present in the complexes formed in measurable concentrations in these systems. The options for the quantitative evaluation of metal binding effectivity and selectivity of the various ligands and the comparison with each other by using solution equilibrium data are also discussed. |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26122ee107a28e7783f6705c9a6d0c50 https://pubmed.ncbi.nlm.nih.gov/35163937 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26122ee107a28e7783f6705c9a6d0c50 |
| قاعدة البيانات: | OpenAIRE |
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