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Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent

التفاصيل البيبلوغرافية
العنوان: Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent
المؤلفون: Julia W. Grimstead, Jacob Zimbric, Nicole H. Heppel, Duncan M. Baird, Kate Liddiard, Sehyun Oh, Eric A. Hendrickson, Laureline Roger, Rhiannon E. Jones, Kevin E. Ashelford
المساهمون: Structure et Instabilité des Génomes (STRING), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Muséum national d'Histoire naturelle (MNHN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Cell Reports
Cell Reports, Elsevier Inc, 2014, 8 (4), pp.1063-1076. ⟨10.1016/j.celrep.2014.07.007⟩
Cell Reports, Vol 8, Iss 4, Pp 1063-1076 (2014)
Cell Reports, 2014, 8 (4), pp.1063-1076. ⟨10.1016/j.celrep.2014.07.007⟩
بيانات النشر: HAL CCSD, 2014.
سنة النشر: 2014
مصطلحات موضوعية: DNA End-Joining Repair, DNA Ligases, [SDV]Life Sciences [q-bio], Apoptosis, [SDV.CAN]Life Sciences [q-bio]/Cancer, LIG3, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, LIG4, Xenopus Proteins, Somatic evolution in cancer, General Biochemistry, Genetics and Molecular Biology, Dicentric chromosome, DNA Ligase ATP, Telomere Homeostasis, Catalytic Domain, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Poly-ADP-Ribose Binding Proteins, lcsh:QH301-705.5, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Genetics, Recombination, Genetic, DNA ligase, fungi, HCT116 Cells, Telomere, chemistry, lcsh:Biology (General), [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
الوصف: SummaryShort dysfunctional telomeres are capable of fusion, generating dicentric chromosomes and initiating breakage-fusion-bridge cycles. Cells that escape the ensuing cellular crisis exhibit large-scale genomic rearrangements that drive clonal evolution and malignant progression. We demonstrate that there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4), to facilitate the escape from a telomere-driven crisis. LIG3- and LIG4-dependent alternative (A) and classical (C) nonhomologous end-joining (NHEJ) pathways were capable of mediating the fusion of short dysfunctional telomeres, both displaying characteristic patterns of microhomology and deletion. Cells that failed to escape crisis exhibited increased proportions of C-NHEJ-mediated interchromosomal fusions, whereas those that escaped displayed increased proportions of intrachromosomal fusions. We propose that the balance between inter- and intrachromosomal telomere fusions dictates the ability of human cells to escape crisis and is influenced by the relative activities of A- and C-NHEJ at short dysfunctional telomeres.
اللغة: English
تدمد: 2211-1247
DOI: 10.1016/j.celrep.2014.07.007⟩
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c64dfa69f72f64f951085ba311f7e9
https://hal.archives-ouvertes.fr/hal-03204504
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....20c64dfa69f72f64f951085ba311f7e9
قاعدة البيانات: OpenAIRE
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