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Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma

التفاصيل البيبلوغرافية
العنوان: Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma
المؤلفون: Erin Tracy, Barbara W. Henderson, Mihai Merzianu, Gregory E. Wilding, Michelle T. Cooper, Daniel J. Rohrbach, Nestor R. Rigual, Gal Shafirstein, Ulas Sunar, Hassan Arshad, Heinz Baumann
المصدر: Journal of biomedical optics. 21(1)
سنة النشر: 2015
مصطلحات موضوعية: 0301 basic medicine, STAT3 Transcription Factor, 030103 biophysics, Pathology, medicine.medical_specialty, medicine.medical_treatment, Biomedical Engineering, Photodynamic therapy, 01 natural sciences, 010309 optics, Biomaterials, 03 medical and health sciences, 0103 physical sciences, Biopsy, Medicine, Humans, Basal cell, Photosensitizer, Mouth neoplasm, Photosensitizing Agents, medicine.diagnostic_test, business.industry, Spectrum Analysis, Blood flow, Oxygenation, medicine.disease, Head and neck squamous-cell carcinoma, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Photochemotherapy, Research Papers: Therapeutic, Carcinoma, Squamous Cell, Mouth Neoplasms, Nuclear medicine, business
الوصف: This study investigated whether diffuse optical spectroscopy (DOS) measurements could assess clinical response to photodynamic therapy (PDT) in patients with head and neck squamous cell carcinoma (HNSCC). In addition, the correlation between parameters measured with DOS and the crosslinking of signal transducer and activator of transcription 3 (STAT3), a molecular marker for PDT-induced photoreaction, was investigated. Thirteen patients with early stage HNSCC received the photosensitizer 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH) and DOS measurements were performed before and after PDT in the operating room (OR). In addition, biopsies were acquired after PDT to assess the STAT3 crosslinking. Parameters measured with DOS, including blood volume fraction, blood oxygen saturation (StO2), HPPH concentration (cHPPH), HPPH fluorescence, and blood flow index (BFI), were compared to the pathologic response and the STAT3 crosslinking. The best individual predictor of pathological response was a change in cHPPH (sensitivity=60%, specificity=100%), while discrimination analysis using a two-parameter classifier (change in cHPPH and change in StO2) classified pathological response with 100% sensitivity and 100% specificity. BFI showed the best correlation with the crosslinking of STAT3. These results indicate that DOS-derived parameters can assess the clinical response in the OR, allowing for earlier reintervention if needed.
تدمد: 1560-2281
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d69884143059add2f49a164dab7fb07
https://pubmed.ncbi.nlm.nih.gov/26780226
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....1d69884143059add2f49a164dab7fb07
قاعدة البيانات: OpenAIRE
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