Transdermal Delivery Devices: Fabrication, Mechanics and Drug Release from Silk
| العنوان: | Transdermal Delivery Devices: Fabrication, Mechanics and Drug Release from Silk |
|---|---|
| المؤلفون: | Abdurrahman Abdurrob, Izzuddin M. Diwan, David L. Kaplan, Waseem K. Raja, Fiorenzo G. Omenetto, Scott MacCorkle, Jessica Lu |
| المصدر: | Small. 9:3704-3713 |
| بيانات النشر: | Wiley, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Drug, Materials science, Fabrication, Biocompatibility, media_common.quotation_subject, Silk, Biocompatible Materials, Nanotechnology, engineering.material, Administration, Cutaneous, Article, Biomaterials, Drug Delivery Systems, Coating, Cadaver, Humans, General Materials Science, Skin, media_common, Transdermal, fungi, technology, industry, and agriculture, Biomaterial, General Chemistry, SILK, Needles, Microscopy, Electron, Scanning, engineering, Drug release, Biotechnology |
| الوصف: | Microneedles are a relatively simple, minimally invasive and painless approach to deliver drugs across the skin. However, there remain limitations with this approach because of the materials most commonly utilized for such systems. Silk protein, with tunable and biocompatibility properties, is a useful biomaterial to overcome the current limitations with microneedles. Silk devices preserve drug activity, offer superior mechanical properties and biocompatibility, can be tuned for biodegradability, and can be processed under aqueous, benign conditions. In the present work, the fabrication of dense microneedle arrays from silk with different drug release kinetics is reported. The mechanical properties of the microneedle patches are tuned by post-fabrication treatments or by loading the needles with silk microparticles, to increase capacity and mechanical strength. Drug release is further enhanced by the encapsulation of the drugs in the silk matrix and coating with a thin dissolvable drug layer. The microneedles are used on human cadaver skin and drugs are delivered successfully. The various attributes demonstrated suggest that silk-based microneedle devices can provide significant benefit as a platform material for transdermal drug delivery. |
| تدمد: | 1613-6810 |
| DOI: | 10.1002/smll.201202075 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c09d05fdc5240c93af0b4860f1e15e8 https://doi.org/10.1002/smll.201202075 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1c09d05fdc5240c93af0b4860f1e15e8 |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi.dedup.....1c09d05fdc5240c93af0b4860f1e15e8 799 3 unknown 798.943176269531 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....1c09d05fdc5240c93af0b4860f1e15e8&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c09d05fdc5240c93af0b4860f1e15e8# [Name] => EDS - OpenAIRE [Category] => fullText [Text] => View record in OpenAIRE [MouseOverText] => View record in OpenAIRE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Transdermal Delivery Devices: Fabrication, Mechanics and Drug Release from Silk
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Abdurrahman+Abdurrob%22">Abdurrahman Abdurrob</searchLink><br /><searchLink fieldCode="AR" term="%22Izzuddin+M%2E+Diwan%22">Izzuddin M. Diwan</searchLink><br /><searchLink fieldCode="AR" term="%22David+L%2E+Kaplan%22">David L. Kaplan</searchLink><br /><searchLink fieldCode="AR" term="%22Waseem+K%2E+Raja%22">Waseem K. Raja</searchLink><br /><searchLink fieldCode="AR" term="%22Fiorenzo+G%2E+Omenetto%22">Fiorenzo G. Omenetto</searchLink><br /><searchLink fieldCode="AR" term="%22Scott+MacCorkle%22">Scott MacCorkle</searchLink><br /><searchLink fieldCode="AR" term="%22Jessica+Lu%22">Jessica Lu</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <i>Small</i>. 9:3704-3713 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Wiley, 2013. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2013 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Drug%22">Drug</searchLink><br /><searchLink fieldCode="DE" term="%22Materials+science%22">Materials science</searchLink><br /><searchLink fieldCode="DE" term="%22Fabrication%22">Fabrication</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22media%5Fcommon%2Equotation%5Fsubject%22">media_common.quotation_subject</searchLink><br /><searchLink fieldCode="DE" term="%22Silk%22">Silk</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatible+Materials%22">Biocompatible Materials</searchLink><br /><searchLink fieldCode="DE" term="%22Nanotechnology%22">Nanotechnology</searchLink><br /><searchLink fieldCode="DE" term="%22engineering%2Ematerial%22">engineering.material</searchLink><br /><searchLink fieldCode="DE" term="%22Administration%2C+Cutaneous%22">Administration, Cutaneous</searchLink><br /><searchLink fieldCode="DE" term="%22Article%22">Article</searchLink><br /><searchLink fieldCode="DE" term="%22Biomaterials%22">Biomaterials</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+Delivery+Systems%22">Drug Delivery Systems</searchLink><br /><searchLink fieldCode="DE" term="%22Coating%22">Coating</searchLink><br /><searchLink fieldCode="DE" term="%22Cadaver%22">Cadaver</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22General+Materials+Science%22">General Materials Science</searchLink><br /><searchLink fieldCode="DE" term="%22Skin%22">Skin</searchLink><br /><searchLink fieldCode="DE" term="%22media%5Fcommon%22">media_common</searchLink><br /><searchLink fieldCode="DE" term="%22Transdermal%22">Transdermal</searchLink><br /><searchLink fieldCode="DE" term="%22fungi%22">fungi</searchLink><br /><searchLink fieldCode="DE" term="%22technology%2C+industry%2C+and+agriculture%22">technology, industry, and agriculture</searchLink><br /><searchLink fieldCode="DE" term="%22Biomaterial%22">Biomaterial</searchLink><br /><searchLink fieldCode="DE" term="%22General+Chemistry%22">General Chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22SILK%22">SILK</searchLink><br /><searchLink fieldCode="DE" term="%22Needles%22">Needles</searchLink><br /><searchLink fieldCode="DE" term="%22Microscopy%2C+Electron%2C+Scanning%22">Microscopy, Electron, Scanning</searchLink><br /><searchLink fieldCode="DE" term="%22engineering%22">engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+release%22">Drug release</searchLink><br /><searchLink fieldCode="DE" term="%22Biotechnology%22">Biotechnology</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Microneedles are a relatively simple, minimally invasive and painless approach to deliver drugs across the skin. However, there remain limitations with this approach because of the materials most commonly utilized for such systems. Silk protein, with tunable and biocompatibility properties, is a useful biomaterial to overcome the current limitations with microneedles. Silk devices preserve drug activity, offer superior mechanical properties and biocompatibility, can be tuned for biodegradability, and can be processed under aqueous, benign conditions. In the present work, the fabrication of dense microneedle arrays from silk with different drug release kinetics is reported. The mechanical properties of the microneedle patches are tuned by post-fabrication treatments or by loading the needles with silk microparticles, to increase capacity and mechanical strength. Drug release is further enhanced by the encapsulation of the drugs in the silk matrix and coating with a thin dissolvable drug layer. The microneedles are used on human cadaver skin and drugs are delivered successfully. The various attributes demonstrated suggest that silk-based microneedle devices can provide significant benefit as a platform material for transdermal drug delivery. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1613-6810 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1002/smll.201202075 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c09d05fdc5240c93af0b4860f1e15e8" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c09d05fdc5240c93af0b4860f1e15e8</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1002/smll.201202075" linkWindow="_blank">https://doi.org/10.1002/smll.201202075</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....1c09d05fdc5240c93af0b4860f1e15e8 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1002/smll.201202075
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 10
[StartPage] => 3704
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Drug
[Type] => general
)
[1] => Array
(
[SubjectFull] => Materials science
[Type] => general
)
[2] => Array
(
[SubjectFull] => Fabrication
[Type] => general
)
[3] => Array
(
[SubjectFull] => Biocompatibility
[Type] => general
)
[4] => Array
(
[SubjectFull] => media_common.quotation_subject
[Type] => general
)
[5] => Array
(
[SubjectFull] => Silk
[Type] => general
)
[6] => Array
(
[SubjectFull] => Biocompatible Materials
[Type] => general
)
[7] => Array
(
[SubjectFull] => Nanotechnology
[Type] => general
)
[8] => Array
(
[SubjectFull] => engineering.material
[Type] => general
)
[9] => Array
(
[SubjectFull] => Administration, Cutaneous
[Type] => general
)
[10] => Array
(
[SubjectFull] => Article
[Type] => general
)
[11] => Array
(
[SubjectFull] => Biomaterials
[Type] => general
)
[12] => Array
(
[SubjectFull] => Drug Delivery Systems
[Type] => general
)
[13] => Array
(
[SubjectFull] => Coating
[Type] => general
)
[14] => Array
(
[SubjectFull] => Cadaver
[Type] => general
)
[15] => Array
(
[SubjectFull] => Humans
[Type] => general
)
[16] => Array
(
[SubjectFull] => General Materials Science
[Type] => general
)
[17] => Array
(
[SubjectFull] => Skin
[Type] => general
)
[18] => Array
(
[SubjectFull] => media_common
[Type] => general
)
[19] => Array
(
[SubjectFull] => Transdermal
[Type] => general
)
[20] => Array
(
[SubjectFull] => fungi
[Type] => general
)
[21] => Array
(
[SubjectFull] => technology, industry, and agriculture
[Type] => general
)
[22] => Array
(
[SubjectFull] => Biomaterial
[Type] => general
)
[23] => Array
(
[SubjectFull] => General Chemistry
[Type] => general
)
[24] => Array
(
[SubjectFull] => SILK
[Type] => general
)
[25] => Array
(
[SubjectFull] => Needles
[Type] => general
)
[26] => Array
(
[SubjectFull] => Microscopy, Electron, Scanning
[Type] => general
)
[27] => Array
(
[SubjectFull] => engineering
[Type] => general
)
[28] => Array
(
[SubjectFull] => Drug release
[Type] => general
)
[29] => Array
(
[SubjectFull] => Biotechnology
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Transdermal Delivery Devices: Fabrication, Mechanics and Drug Release from Silk
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Abdurrahman Abdurrob
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Izzuddin M. Diwan
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => David L. Kaplan
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Waseem K. Raja
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Fiorenzo G. Omenetto
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Scott MacCorkle
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jessica Lu
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 08
[M] => 05
[Type] => published
[Y] => 2013
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 16136810
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 9
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Small
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |