Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly
| العنوان: | Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly |
|---|---|
| المؤلفون: | Wladimir M. Freitas, Brasilia Heart Study, Andrei C. Sposito, Wilson Nadruz, Luiz Sergio F. Carvalho, Otavio R. Coelho-Filho, Rodrigo Bueno de Oliveira, Alessandra M. Campos-Staffico, Brasilia Study on Healthy Aging |
| المصدر: | Atherosclerosis. 292:70-74 |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Osteoporosis, Logistic regression, Carotid Intima-Media Thickness, Bone Density, Internal medicine, medicine, Humans, Prospective Studies, Endothelial dysfunction, Aged, Aged, 80 and over, business.industry, Age Factors, Odds ratio, Atherosclerosis, medicine.disease, Pathophysiology, Coronary Calcium Score, Cross-Sectional Studies, Cohort, Cardiology, Female, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, Calcification |
| الوصف: | Background and aims Osteoporosis and coronary heart disease (CHD) are very common conditions among elderly people, and both represent a public health concern due to their prognostic consequences. Osteoporosis and CHD share many risk factors and pathophysiological mechanisms, such as calcification pathways. Clinical evidence associates lower bone mass with cardiovascular diseases and endothelial dysfunction. Hence, this study aims to investigate whether bone mass density is associated with subclinical atherosclerosis and/or endothelial dysfunction in the very elderly. Methods We performed a cross-sectional study of cohort enrolled individuals, ages 80 years or older (n = 208), who had never manifested cardiovascular diseases. Medical evaluation, blood tests, flow-mediated dilation (FMD), carotid intimal-media thickness (IMT), Dual Energy X-ray Absorptiometry (DEXA) and Coronary Calcium Score (CCS) were obtained. Odds Ratio (OR) was calculated by multivariate logistic regression models using CCS, FMD and IMT categories. Adjustments for covariates were done. Results Overall bone mass was independently and inversely associated with CCS categories [OR:1.68(1.16–8.85); p = 0.024] and IMT categories [OR:2.97(1.11–7.90); p = 0.030]. Conversely, overall bone mass was independent and directly associated with FMD categories [OR:2.73(1.36–70.39); p = 0.023]. Conclusions This study indicates that overall bone mass is independently and inversely associated with subclinical atherosclerosis, endothelial dysfunction and thickness of carotid in the very elderly. |
| تدمد: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2019.11.007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18065434b99348a542e05325960fc74e https://doi.org/10.1016/j.atherosclerosis.2019.11.007 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....18065434b99348a542e05325960fc74e |
| قاعدة البيانات: | OpenAIRE |
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Osteoporosis and CHD share many risk factors and pathophysiological mechanisms, such as calcification pathways. Clinical evidence associates lower bone mass with cardiovascular diseases and endothelial dysfunction. Hence, this study aims to investigate whether bone mass density is associated with subclinical atherosclerosis and/or endothelial dysfunction in the very elderly. Methods We performed a cross-sectional study of cohort enrolled individuals, ages 80 years or older (n = 208), who had never manifested cardiovascular diseases. Medical evaluation, blood tests, flow-mediated dilation (FMD), carotid intimal-media thickness (IMT), Dual Energy X-ray Absorptiometry (DEXA) and Coronary Calcium Score (CCS) were obtained. Odds Ratio (OR) was calculated by multivariate logistic regression models using CCS, FMD and IMT categories. Adjustments for covariates were done. Results Overall bone mass was independently and inversely associated with CCS categories [OR:1.68(1.16–8.85); p = 0.024] and IMT categories [OR:2.97(1.11–7.90); p = 0.030]. Conversely, overall bone mass was independent and directly associated with FMD categories [OR:2.73(1.36–70.39); p = 0.023]. 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