Planarity of heteroaryldithiocarbazic acid derivatives showing tuberculostatic activity: structure-activity relationships

التفاصيل البيبلوغرافية
العنوان: Planarity of heteroaryldithiocarbazic acid derivatives showing tuberculostatic activity: structure-activity relationships
المؤلفون: Małgorzata Szczesio, Katarzyna Gobis, Andrzej Olczak, Jolanta Gołka, Czesława Orlewska, Izabela Korona-Glowniak
المصدر: Acta crystallographica. Section C, Structural chemistry. 74(Pt 3)
سنة النشر: 2017
مصطلحات موضوعية: Hydrogen bond, Chemistry, Structure (category theory), Antitubercular Agents, Hydrogen Bonding, Crystal structure, Mycobacterium tuberculosis, Triclinic crystal system, 010402 general chemistry, 010403 inorganic & nuclear chemistry, Condensed Matter Physics, Crystallography, X-Ray, 01 natural sciences, Planarity testing, 0104 chemical sciences, Inorganic Chemistry, Crystallography, Structure-Activity Relationship, Materials Chemistry, Structure–activity relationship, Physical and Theoretical Chemistry, Monoclinic crystal system
الوصف: The search for new tuberculostatics is an important issue due to the increasing resistance ofMycobacterium tuberculosisto existing agents and the resulting spread of the pathogen. Heteroaryldithiocarbazic acid derivatives have shown potential tuberculostatic activity and investigations of the structural aspects of these compounds are thus of interest. Three new examples have been synthesized. The structure of methyl 2-[amino(pyridin-3-yl)methylidene]hydrazinecarbodithioate, C8H10N4S2, at 293 K has monoclinic (P21/n) symmetry. It is of interest with respect to antibacterial properties. The structure displays N—H...N and N—H...S hydrogen bonding. The structure ofN′-(pyrrolidine-1-carbonothioyl)picolinohydrazonamide, C11H15N5S, at 100 K has monoclinic (P21/n) symmetry and is also of interest with respect to antibacterial properties. The structure displays N—H...S hydrogen bonding. The structure of (Z)-methyl 2-[amino(pyridin-2-yl)methylidene]-1-methylhydrazinecarbodithioate, C9H13N4S2, has triclinic (P\overline{1}) symmetry. The structure displays N—H...S hydrogen bonding.
تدمد: 2053-2296
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1629317ca52044673152bcd880437a20
https://pubmed.ncbi.nlm.nih.gov/29504572
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....1629317ca52044673152bcd880437a20
قاعدة البيانات: OpenAIRE