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Hypothalamic-pituitary-thyroid (HPT) axis in chronic alcoholism. I. HPT axis in chronic alcoholics during withdrawal and after 3 weeks of abstinence

التفاصيل البيبلوغرافية
العنوان: Hypothalamic-pituitary-thyroid (HPT) axis in chronic alcoholism. I. HPT axis in chronic alcoholics during withdrawal and after 3 weeks of abstinence
المؤلفون: Andreas Baumgartner, Klaus-Jürgen Gräf, Hans Rommelspacher, Irene Kürten, Werner Platz, Monika Otto, Angel Campos-Barros, Lutz G. Schmidt
المصدر: Alcoholism, clinical and experimental research. 18(2)
سنة النشر: 1994
مصطلحات موضوعية: Adult, Male, endocrine system, medicine.medical_specialty, Hypothalamo-Hypophyseal System, Thyroid Hormones, media_common.quotation_subject, Temperance, Thyroid Gland, Medicine (miscellaneous), Thyroid Function Tests, Toxicology, Alcohol Withdrawal Delirium, Liver disease, Thyroxine-binding globulin, Patient Admission, Liver Function Tests, Internal medicine, Statistical significance, medicine, Humans, Liver Diseases, Alcoholic, media_common, Triiodothyronine, biology, Thyroid, Chronic alcoholic, Abstinence, Middle Aged, medicine.disease, Hypothalamic–pituitary–thyroid axis, Psychiatry and Mental health, Alcoholism, Endocrinology, medicine.anatomical_structure, biology.protein, Female, Substance Abuse Treatment Centers, Psychology, hormones, hormone substitutes, and hormone antagonists
الوصف: Thyroxine (T4), free T4 (fT4), triiodothyronine (T3 free T3 (fT3), reverse T3 (rT3), thyrotropine (TSH), thyroxine binding globulin (TBG), and T3 uptake were measured in 14 chronic alcoholics during withdrawal and after 21 days of abstinence. Results were compared with those of 16 healthy volunteers. During withdrawal, the fT4 and fT3 concentrations were subnormal, whereas the respective protein-bound fractions were normal. T4, T3, and TBG increased during the abstinence period, T3 and TBG being significantly higher than in normals at the second measuring time. T3 uptake values fell, but remained well within the normal range at both measuring times. During abstinence, the fT3 levels remained significantly lower than in healthy subjects. rT3 concentrations decreased, but not significantly. The TSH values were normal throughout. These results showed numerous abnormalities in the hypothal-amic-pituitary-thyroid axis in alcoholics, the reasons for which are as yet unclear. The following possible interpretations are suggested: 1. The abnormally low serum fT3 and ff4 levels during withdrawal might reflect an increase in tissue uptake. 2. The increases in T4-and partty those in T3-during abstinence seem to reflect increased binding by TBG, the level of which rose markedly for reasons as yet unknown. 3. If increases in TBG during abstinence are taken into account, the decreases in rT3 concentrations may reach the level of statistical significance. These falls in rT3 concentrations may reflect an increase in rT3 metabolization (deiodination) in various tissues, including the CNS, leading to a reduction in serum rT3 bioavail-ability. 4. Factors such as liver disease, protein caloric malnutrition, and “psychological stress” do not fully explain all these abnormalities. A direct effect of ethanol on intracellular thyroid hormone metabolism and/or function seems conceivable.
تدمد: 0145-6008
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ec387fee953640d477ec8f33c64a3d
https://pubmed.ncbi.nlm.nih.gov/8048729
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....15ec387fee953640d477ec8f33c64a3d
قاعدة البيانات: OpenAIRE
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