Top2a promotes the development of social behavior via PRC2 and H3K27me3
| العنوان: | Top2a promotes the development of social behavior via PRC2 and H3K27me3 |
|---|---|
| المؤلفون: | Yijie Geng, Tejia Zhang, Ivy G. Alonzo, Sean C. Godar, Christopher Yates, Brock R. Pluimer, Devin L. Harrison, Anjali K. Nath, Jing-Ruey Joanna Yeh, Iain A. Drummond, Marco Bortolato, Randall T. Peterson |
| المصدر: | Science Advances. 8 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | Little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting social deficits in zebrafish. In mice, prenatal Top2 inhibition caused defects in social interaction and communication, which are behaviors that relate to core symptoms of autism. Mutation of Top2a in zebrafish caused down-regulation of a set of genes highly enriched for genes associated with autism in humans. Both the Top2a-regulated and autism-associated gene sets have binding sites for polycomb repressive complex 2 (PRC2), a regulatory complex responsible for H3K27 trimethylation (H3K27me3). Moreover, both gene sets are highly enriched for H3K27me3. Inhibition of the PRC2 component Ezh2 rescued social deficits caused by Top2 inhibition. Therefore, Top2a is a key component of an evolutionarily conserved pathway that promotes the development of social behavior through PRC2 and H3K27me3. |
| تدمد: | 2375-2548 |
| DOI: | 10.1126/sciadv.abm7069 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d15df17eec9eec2ee92815626d99da https://doi.org/10.1126/sciadv.abm7069 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....11d15df17eec9eec2ee92815626d99da |
| قاعدة البيانات: | OpenAIRE |
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