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In community-dwelling women frailty is associated with imminent risk of osteoporotic fractures

التفاصيل البيبلوغرافية
العنوان: In community-dwelling women frailty is associated with imminent risk of osteoporotic fractures
المؤلفون: Kristina Åkesson, P. Bartosch, Fiona E. McGuigan, Linnea Malmgren, Jimmie Kristensson
المصدر: Osteoporosis International
بيانات النشر: Springer London, 2021.
سنة النشر: 2021
مصطلحات موضوعية: 0301 basic medicine, Gerontology, medicine.medical_specialty, Bone density, Endocrinology, Diabetes and Metabolism, Frail Elderly, 030209 endocrinology & metabolism, Long terms, Community dwelling, 03 medical and health sciences, 0302 clinical medicine, BMD, Bone Density, Internal medicine, medicine, Humans, Frail elderly, Women, Aged, Bone mineral, Frailty, business.industry, Rheumatology, Fracture, Quartile, Orthopedic surgery, Cohort, Original Article, Female, 030101 anatomy & morphology, Independent Living, business, Osteoporotic Fractures
الوصف: Summary Frailty reflects an accelerated health decline. Frailty is a consequence of fracture and contributes to fracture. Greater frailty was associated with higher fracture risk. Frail women were at immediate risk (within 24 months) of a hip or major fracture. Fracture prevention could be improved by considering frailty status. Introduction Frailty encompasses the functional decline in multiple systems, particularly the musculoskeletal system. Frailty can be a consequence of and contribute to fracture, leading to a cycle of further fractures and greater frailty. This study investigates this association, specifically time frames for risk, associated fracture types, and how grade of frailty affects risk. Methods The study is performed in the OPRA cohort of 1044, 75-year-old women. A frailty index was created at baseline and 5 and 10 years. Women were categorized as frail or nonfrail and in quartiles (Q1 least frail; Q4 most frail). Fracture risk was assessed over short (1 and 2 years) and long terms (5 and 10 years). Fracture risk was defined for any fracture, major osteoporotic fractures (MOFs), and hip and vertebral fracture, using models including bone mineral density (BMD) and death as a competing risk. Results For women aged 75, frailty was associated with higher risk of fracture within 2 years (Hip SHRadj. 3.16 (1.34–7.47)) and MOF (2 years SHRadj. 1.88 (1.12–3.16)). The increased risk continued for up to 5 years (Hip SHRadj. 2.02 (1.07–3.82)); (MOF SHRadj. 1.43 (0.99–2.05)). Grade of frailty was associated with increased 10-year probability of fracture (p = 0.03). Frailty predicted fracture independently of BMD. For women aged 80, frailty was similarly associated with fracture. Conclusion Frail elderly women are at immediate risk of fracture, regardless of bone density and continue to be at risk over subsequent years compared to identically aged nonfrail women. Incorporating regular frailty assessment into fracture management could improve identification of women at high fracture risk. Supplementary Information The online version contains supplementary material available at 10.1007/s00198-021-05886-7.
اللغة: English
تدمد: 1433-2965
0937-941X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1a4d4e7de6944421fd8466f15adf99
http://europepmc.org/articles/PMC8387253
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....0c1a4d4e7de6944421fd8466f15adf99
قاعدة البيانات: OpenAIRE
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