Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex
| العنوان: | Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex |
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| المؤلفون: | Dean Toy, Tim Vanden Bos, Martin F. Wolfson, David G. Kugler, Jesse L. Gurgel, Jonathan M.J. Derry, Jacques J. Peschon, Joel Tocker |
| المصدر: | The Journal of Immunology. 177:36-39 |
| بيانات النشر: | The American Association of Immunologists, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Chemokine, Receptor complex, Stromal cell, medicine.medical_treatment, Receptor expression, Immunology, Ligands, Cell Line, Proinflammatory cytokine, Mice, medicine, Animals, Humans, Immunology and Allergy, Receptor, Cell Line, Transformed, Mice, Knockout, Receptors, Interleukin-17, biology, Interleukin-17, Receptors, Interleukin, Fibroblasts, Cell biology, Mice, Inbred C57BL, Protein Subunits, Cytokine, biology.protein, Interleukin 17, Signal Transduction |
| الوصف: | IL-17 is an inflammatory cytokine produced primarily by a unique lineage of CD4 T cells that plays critical roles in the pathogenesis of multiple autoimmune diseases. IL-17RA is a ubiquitously expressed receptor that is essential for IL-17 biologic activity. Despite widespread receptor expression, the activity of IL-17 is most classically defined by its ability to induce the expression of inflammatory cytokines, chemokines, and other mediators by stromal cells. The lack of IL-17 responsiveness in mouse stromal cells genetically deficient in IL-17RA is poorly complemented by human IL-17RA, suggesting the presence of an obligate ancillary component whose activity is species specific. This component is IL-17RC, a distinct member of the IL-17R family. Thus, the biologic activity of IL-17 is dependent on a complex composed of IL-17RA and IL-17RC, suggesting a new paradigm for understanding the interactions between the expanded family of IL-17 ligands and their receptors. |
| تدمد: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.177.1.36 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e5cdadb41ba16fad5a1ef2a509fe58 https://doi.org/10.4049/jimmunol.177.1.36 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....07e5cdadb41ba16fad5a1ef2a509fe58 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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| DOI: | 10.4049/jimmunol.177.1.36 |