Environmental Effects Determine the Structure of Potential β-Amino Acid Based Foldamers
| العنوان: | Environmental Effects Determine the Structure of Potential β-Amino Acid Based Foldamers |
|---|---|
| المؤلفون: | Miriam Royo, Jesús Jiménez-Barbero, Víctor M. Sánchez-Pedregal, Rosalino Balo, Juan C. Estévez, Ana Ardá, Fredy Sussman, M. Carmen Villaverde, Ramón J. Estévez, Ana Gimeno |
| المصدر: | Chemistry - A European Journal. 24:10625-10629 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Stereochemistry, Amino Acids, Basic, Organic Chemistry, General Chemistry, Nuclear magnetic resonance spectroscopy, 010402 general chemistry, 01 natural sciences, Micelle, Catalysis, 0104 chemical sciences, Amino acid, Molecular dynamics, Solvents, Cycloleucine, Peptides |
| الوصف: | This work shows that hybrid peptides formed by alternating trans-2-aminocyclopentanecarboxylic acid (trans-ACPC) and trans-2-aminocyclohexanecarboxylic acid (trans-ACHC) do not fold in the solvents typically used in the study of their homo-oligomers. Only when the peptides are assayed in SDS micelles are the predicted helical structures obtained. This indicates that the environment could play an equally important role (as the backbone stereochemistry) in determining their fold, possibly by providing a sequestered environment. |
| تدمد: | 0947-6539 |
| DOI: | 10.1002/chem.201801953 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051e357d6f44b1b60cf4a264bf2efa82 https://doi.org/10.1002/chem.201801953 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....051e357d6f44b1b60cf4a264bf2efa82 |
| قاعدة البيانات: | OpenAIRE |
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