DNA methylation and transcription in a distal region upstream from the bovine alphaS1 casein gene after once or twice daily milking
| العنوان: | DNA methylation and transcription in a distal region upstream from the bovine alphaS1 casein gene after once or twice daily milking |
|---|---|
| المؤلفون: | Hélène Jammes, Stephan Bouet, Clémence Kress, Eve Devinoy, Madia Charlier, Barbara Petridou, Christophe Klopp, Marion Boutinaud, Maëlle Pannetier, Anne Gabory, Denis Laloë, Luc Jouneau, Florence Jaffrézic, Nicolas Brun, Sophie Chat, Minh Nguyen |
| المساهمون: | Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA), Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Unité de Biométrie et Intelligence Artificielle (UBIA), Institut National de la Recherche Agronomique (INRA), Institut cellule souche et cerveau (U846 Inserm - UCBL1), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR EpigRAni (2010-2014), Devinoy, Eve, ProdInra, Archive Ouverte, Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT) (UBIA), Biologie du Développement et Reproduction (BDR), Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (SBRI), Université Claude Bernard Lyon 1 (UCBL) |
| المصدر: | PLoS ONE PLoS ONE, Public Library of Science, 2014, 9 (11), pp.1-17. ⟨10.1371/journal.pone.0111556⟩ www.plosone.org Plos One 11 (9), 1-17. (2014) PLoS ONE, 2014, 9 (11), pp.1-17. ⟨10.1371/journal.pone.0111556⟩ PLoS ONE, Vol 9, Iss 11, p e111556 (2014) |
| بيانات النشر: | HAL CCSD, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Transcription, Genetic, Peptide Hormones, [SDV]Life Sciences [q-bio], lcsh:Medicine, Biochemistry, Transcription (biology), Animal Products, Lactation, Gene expression, Molecular Cell Biology, Udder, lcsh:Science, Animal Management, 2. Zero hunger, 0303 health sciences, Multidisciplinary, Chromosome Biology, Caseins, Agriculture, 04 agricultural and veterinary sciences, Methylation, [SDV] Life Sciences [q-bio], Dairying, medicine.anatomical_structure, Milk, CpG site, Multigene Family, DNA methylation, Female, Epigenetics, Research Article, medicine.medical_specialty, Livestock, Molecular Sequence Data, Biology, Milking, Promoter Regions, 03 medical and health sciences, Mammary Glands, Animal, épigénétique, Internal medicine, medicine, Genetics, Animals, Caséine, ARNnc, épigénétique, Molecular Biology, 030304 developmental biology, ARNnc, Base Sequence, lcsh:R, 0402 animal and dairy science, Biology and Life Sciences, DNA, Cell Biology, DNA Methylation, 040201 dairy & animal science, Peptide Fragments, Hormones, Prolactin, Endocrinology, lcsh:Q, Cattle, Caséine, Developmental Biology |
| الوصف: | Once daily milking (ODM) induces a reduction in milk production when compared to twice daily milking (TDM). Unilateral ODM of one udder half and TDM of the other half, enables the study of underlying mechanisms independently of inter-individual variability (same genetic background) and of environmental factors. Our results show that in first-calf heifers three CpG, located 10 kb upstream from the CSN1S1 gene were methylated to 33, 34 and 28%, respectively, after TDM but these levels were higher after ODM, 38, 38 and 33%, respectively. These methylation levels were much lower than those observed in the mammary gland during pregnancy (57, 59 and 50%, respectively) or in the liver (74, 78 and 61%, respectively). The methylation level of a fourth CpG (CpG4), located close by (29% during TDM) was not altered after ODM. CpG4 methylation reached 39.7% and 59.5%, during pregnancy or in the liver, respectively. CpG4 is located within a weak STAT5 binding element, arranged in tandem with a second high affinity STAT5 element. STAT5 binding is only marginally modulated by CpG4 methylation, but it may be altered by the methylation levels of the three other CpG nearby. Our results therefore shed light on mechanisms that help to explain how milk production is almost, but not fully, restored when TDM is resumed (15.1 ± 0.2 kg/day instead of 16.2 ± 0.2 kg/day, p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0111556⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fcc97070b32508c7732b15e7b9be76 https://hal.archives-ouvertes.fr/hal-01193988/document |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....04fcc97070b32508c7732b15e7b9be76 |
| قاعدة البيانات: | OpenAIRE |
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Unilateral ODM of one udder half and TDM of the other half, enables the study of underlying mechanisms independently of inter-individual variability (same genetic background) and of environmental factors. Our results show that in first-calf heifers three CpG, located 10 kb upstream from the CSN1S1 gene were methylated to 33, 34 and 28%, respectively, after TDM but these levels were higher after ODM, 38, 38 and 33%, respectively. These methylation levels were much lower than those observed in the mammary gland during pregnancy (57, 59 and 50%, respectively) or in the liver (74, 78 and 61%, respectively). The methylation level of a fourth CpG (CpG4), located close by (29% during TDM) was not altered after ODM. CpG4 methylation reached 39.7% and 59.5%, during pregnancy or in the liver, respectively. CpG4 is located within a weak STAT5 binding element, arranged in tandem with a second high affinity STAT5 element. STAT5 binding is only marginally modulated by CpG4 methylation, but it may be altered by the methylation levels of the three other CpG nearby. 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