Five-year follow-up of children with perinatal HIV-1 infection receiving early highly active antiretroviral therapy
| العنوان: | Five-year follow-up of children with perinatal HIV-1 infection receiving early highly active antiretroviral therapy |
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| المؤلفون: | Author:, Chiappini, Galli, E, Tovo, L, Gabiano, Pa, Lisi, C, Bernardi, C, Vigano, S, Guarino, A, Giaquinto, A, Esposito, C, Badolato, S, R, Bari, Di, Rosso, C, Genovese, R, Masi, O, Mazza, M, A, Martino, De, Italian Register for HIV Infection Other Partecipants: Osimani, M., Cordiali, P, Mattia, De, Manzinonna, D, M, Ruggeri, C, Masi, M, Miniaci, M, Specchia, A, Ciccia, F, Lanari, M, Baldi, M, Battisti, F, Bertulli, L, Dessì, C, Pintor, C, Dedoni, C, Fenu, M, Cavallini, Ml, Anastasio, R, Magnolia, E, Sticca, Mg, Pomero, M, Bezzi, G, Fiumana, T, Bonsignori, E, F, Gaudio, De, Gervaso, M, Cecchi, P, Viscoli, Mt, Cosso, C, Timitilli, D, Stronati, A, Plebani, M, Semino, A, Tei, M, Giacomet, F, Pivetti, V, Salvini, V, Zuccotti, F, Giovannini, Gv, Ferraris, M, Liprieri, G, Moretti, R, Cellini, C, Cano, M, Paolucci, Mc, Bruzzese, P, Giannattasio, E, Tarallo, A, Tancredi, L, Pennazzato, F, Rampon, M, O, Dalle, Nogare, Sanfilippo, Er, Romano, A, Saitta, M, Dodi, I, Bandello, M, Maccabruni, A, Felici, L, Consolini, Rita |
| المساهمون: | Chiappini E., Galli L., Tovo PA., Gabiano C., Lisi C., Bernardi S., Viganò A., Guarino A., Giaquinto C., Esposito S., Badolato R., Di Bari C., Rosso R., Genovese O., Masi M., Mazza A., de Martino M., Specchia F., Molesini M., Chiappini, E., Galli, L., Tovo, P. -A., Gabiano, C., Lisi, C., Bernardi, S., Vigano, A., Guarino, A., Giaquinto, C., Esposito, S., Badolato, R., Di Bari, C., Rosso, R., Genovese, O., Masi, M., Mazza, A., De Martino, M. |
| المصدر: | BMC Infectious Diseases, Vol 9, Iss 1, p 140 (2009) BMC Infectious Diseases |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pediatrics, Anti-HIV Agents, HIV Infections, Follow-Up Studie, lcsh:Infectious and parasitic diseases, Pharmacotherapy, Medical microbiology, Interquartile range, Antiretroviral Therapy, Highly Active, medicine, Humans, HIV Infection, lcsh:RC109-216, Child, Pregnancy, business.industry, Anti-HIV Agent, Infant, Viral Load, medicine.disease, Antiretroviral therapy, hiv children, CD4 Lymphocyte Count, Regimen, Infectious Diseases, Italy, Child, Preschool, Tropical medicine, Immunology, HIV-1, RNA, Viral, business, Viral load, Research Article, Follow-Up Studies, Human |
| الوصف: | Background Early highly active antiretroviral therapy (HAART), started within the first months of age, has been proven to be the optimal strategy to prevent immunological and clinical deterioration in perinatally HIV-infected children. Nevertheless, data about long-term follow-up of early treated children are lacking. Methods We report data from 40 perinatally HIV-infected-children receiving early HAART, with a median follow-up period of 5.96 years (interquartile range [IQR]:4.21–7.62). Children were enrolled at birth in the Italian Register for HIV Infection in Children. Comparison with 91 infected children born in the same period, followed-up from birth, and receiving deferred treatment was also provided. Results Nineteen children (47.5%) were still receiving their first HAART regimen at last follow-up. In the remaining children the first regimen was discontinued, after a median period of 3.77 years (IQR: 1.71–5.71) because of viral failure (8 cases), liver toxicity (1 case), structured therapy interruption (3 cases), or simplification/switch to a PI-sparing regimen (9 cases). Thirty-nine (97.5%) children showed CD4+ T-lymphocyte values>25%, and undetectable viral load was reached in 31 (77.5%) children at last visit. Early treated children displayed significantly lower viral load than not-early treated children, until 6 years of age, and higher median CD4+ T-lymphocyte percentages until 4 years of age. Twenty-seven (29.7%) not-early treated vs. 0/40 early treated children were in clinical category C at last follow-up (P < 0.0001). Conclusion Our findings suggest that clinical, virologic and immunological advantages from early-HAART are long-lasting. Recommendations indicating the long-term management of early treated children are needed. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035a1e7ac466bae7c2ae590f14677466 http://hdl.handle.net/11585/101183 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....035a1e7ac466bae7c2ae590f14677466 |
| قاعدة البيانات: | OpenAIRE |
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