Diastereoselective synthesis of 3,3-dimethylazetidines via an intramolecular iodine-mediated cyclization reaction
| العنوان: | Diastereoselective synthesis of 3,3-dimethylazetidines via an intramolecular iodine-mediated cyclization reaction |
|---|---|
| المؤلفون: | Li-Ming Zhao, Wei Zhou, Hai-Shan Jin, Rui Sun |
| المصدر: | RSC Advances. 6:15035-15038 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 010405 organic chemistry, Chemistry, General Chemical Engineering, Bioactive molecules, Synthon, Intramolecular cyclization, chemistry.chemical_element, General Chemistry, 010402 general chemistry, Iodine, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Intramolecular force, Moiety, Organic chemistry, Organic synthesis, Amine gas treating |
| الوصف: | A number of bioactive molecules possess a 3,3-dimethylazetidine moiety. An iodine-mediated intramolecular cyclization reaction of γ-prenylated amines has been developed to provide a convenient route to 3,3-dimethylazetidines in a highly diastereoselective manner. The presented approach not only offers a new strategy for the synthesis of the bioactively important 3,3-dimethylazetidines but also provides an opportunity to extend the application of γ-prenylated amine synthons in organic synthesis. |
| تدمد: | 2046-2069 |
| DOI: | 10.1039/c5ra21872a |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::fdcde6b127224af89e4c358eda2af244 https://doi.org/10.1039/c5ra21872a |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........fdcde6b127224af89e4c358eda2af244 |
| قاعدة البيانات: | OpenAIRE |
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