INHIBITORY EFFECT OF ETHANOLIC EXTRACT OF CURANGA FEL-TERRAE (PUGUN TANO) LEAVES ON ACETYLCHOLINE MUSCARINIC-3 RECEPTORS INDUCED ON ISOLATED GUINEA PIG TRACHEAL
| العنوان: | INHIBITORY EFFECT OF ETHANOLIC EXTRACT OF CURANGA FEL-TERRAE (PUGUN TANO) LEAVES ON ACETYLCHOLINE MUSCARINIC-3 RECEPTORS INDUCED ON ISOLATED GUINEA PIG TRACHEAL |
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| المؤلفون: | Lia Laila, Sri Yuliasmi, Henny Sri Wahyuni, Imam Bagus Sumantri, Bayu Eko Prasetyo, Marianne Nil, Popi Patilaya, Dadang Irfan Husori, Urip Harahap |
| المصدر: | Asian Journal of Pharmaceutical and Clinical Research. 10:95 |
| بيانات النشر: | Innovare Academic Sciences Pvt Ltd, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Pharmacology, Contraction (grammar), Chemistry, Pharmaceutical Science, Muscarinic acetylcholine receptor M3, 030209 endocrinology & metabolism, In vitro, Guinea pig, 03 medical and health sciences, 0302 clinical medicine, Biochemistry, Competitive antagonist, medicine, Pharmacology (medical), 030212 general & internal medicine, Receptor, Incubation, Acetylcholine, medicine.drug |
| الوصف: | Objective: The study was aimed to investigate the inhibitory effect of ethanolic extract of Curanga fel-terrae leaves (EECFL) against acetylcholine (ACh)-induced contraction of the ACh-muscarinic-3 receptor. Materials and Methods: The study of the inhibitory effect of the ethanolic extract on the contraction by ACh concentration series (10−8-10−3 M) was conducted in vitro using isolated guinea pig tracheal organ in the Krebs solution. R esults: Early incubation of tracheal organ with EECFL (0.5, 1, 2 and 4 mg/ml) before contracted by the series of ACh concentration produces the decrease of ACh contraction. The concentration series of ACh sigmoid curve rightward shift without decreasing the maximal contraction. The results of double-reciprocal plot of ACh shows the mean value of the 1/y-intercept of each extract was not different with the control. C onclusion: The EECFL showed competitive antagonist effect on ACh-muscarinic-3 receptors. Ke ywords: C uranga fel-terrae , Pugun tano, Acetylcholine-muscarinic-3 receptors, Competitive antagonist, Ethanolic extract. |
| تدمد: | 2455-3891 0974-2441 |
| DOI: | 10.22159/ajpcr.2017.v10i1.14163 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f7a909b1e0ecc2d7aeb39a9c66426656 https://doi.org/10.22159/ajpcr.2017.v10i1.14163 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........f7a909b1e0ecc2d7aeb39a9c66426656 |
| قاعدة البيانات: | OpenAIRE |
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