S100P as a novel biomarker of microvascular invasion and portal vein tumor thrombus in hepatocellular carcinoma
| العنوان: | S100P as a novel biomarker of microvascular invasion and portal vein tumor thrombus in hepatocellular carcinoma |
|---|---|
| المؤلفون: | Yuan-Yuan Chen, Jian-Hong Zhong, Jiazhou Ye, Liang Ma, Wan-Ting Xing, Hong-Hao Li, Le-Qun Li, Wen-Feng Gong, Fei-Xiang Wu, Bang-De Xiang, Lu-Nan Qi, Jinjie Shang, Zhi-Jun Jiang, Zu-Shun Chen |
| المصدر: | Hepatology International. 15:114-126 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Hepatology, biology, business.industry, CD44, HCCS, medicine.disease, digestive system diseases, Metastasis, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Internal medicine, biology.protein, medicine, Cancer research, Biomarker (medicine), 030211 gastroenterology & hepatology, Differential diagnosis, business, neoplasms, Immunostaining |
| الوصف: | Portal vein tumor thrombus (PVTT) and microvascular invasion (MVI) are types of intrahepatic vascular metastasis of hepatocellular carcinoma (HCC) and are highly correlated with poor prognosis. However, the underlying biomarkers of PVTT and MVI are unclear. We identified a PVTT/MVI-associated gene S100P by cDNA microarray analysis, and assess the potential value of serum S100P measurement in the differential diagnosis of HCC and prediction of MVI status with large retrospective and perspective cohort studies. The mRNA and protein of S100P was increased in HCCs with PVTT or MVI. High S100P immunostaining in tumors was correlated with inferior tumor-free survival. Serum S100P values discriminated patients with HCCs from those with benign liver tumors, and it showed predictive potential of MVI status in both retrospective and perspective cohorts. S100P may regulate HCC tumorigenicity and invasive ability; S100P also was associated with up-regulation of CD44, which may mediate HCC cell adhesion to form PVTT/MVI. Serum S100P may be a novel differential diagnostic marker for HCC and a potential predictor of MVI status pre-surgery for HCC patients. S100P overexpression in HCC is highly correlated with the formation of PVTT and MVI, which may make S100P as a potential therapeutic target for HCC metastasis. |
| تدمد: | 1936-0541 1936-0533 |
| DOI: | 10.1007/s12072-020-10130-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f509e8726019bb7a8bae5cab12c97463 https://doi.org/10.1007/s12072-020-10130-1 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........f509e8726019bb7a8bae5cab12c97463 |
| قاعدة البيانات: | OpenAIRE |
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