Synthesis, resolution and absolute configuration of a tolperisone metabolite
| العنوان: | Synthesis, resolution and absolute configuration of a tolperisone metabolite |
|---|---|
| المؤلفون: | László Párkányi, Zsuzsanna Tuza, Gabriella Egri, Elemér Fogassy, Imre Markovits, József Bálint |
| المصدر: | Tetrahedron: Asymmetry. 12:719-724 |
| بيانات النشر: | Elsevier BV, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Tolperisone, Resolution (mass spectrometry), Stereochemistry, Metabolite, Organic Chemistry, Absolute configuration, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, chemistry, medicine, Tartaric acid, Physical and Theoretical Chemistry, Mannich reaction, Salt formation, Nuclear chemistry, medicine.drug |
| الوصف: | 1-(4′-Hydroxymethyl-phenyl)-2-methyl-3-(piperidine-1-yl)-propane-1-one M2, a metabolite of tolperisone, was synthesised in a solvent-free Mannich reaction. The optical resolution was carried out by diastereoisomeric salt formation and separation, for which three resolving agents ((2R,3R)-O,O′-dibenzoyl tartaric acid, (2R,3R)-O,O′-di-p-toluoyl tartaric acid and (R)-2-hydroxy-4-(2-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaphosphorinane-2-oxide (anicyphos)) were found. The absolute configuration of M2 was determined by the single-crystal X-ray diffraction method. |
| تدمد: | 0957-4166 |
| DOI: | 10.1016/s0957-4166(01)00088-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ebae1093d779d9ae53ea0fddd6466cc6 https://doi.org/10.1016/s0957-4166(01)00088-x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........ebae1093d779d9ae53ea0fddd6466cc6 |
| قاعدة البيانات: | OpenAIRE |
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