Thrombopoietin serum levels do not correlate with thrombocytopenia in hepatic schistosomiasis
| العنوان: | Thrombopoietin serum levels do not correlate with thrombocytopenia in hepatic schistosomiasis |
|---|---|
| المؤلفون: | Durval Rosa Borges, Luciane Aparecida Köpke de Aguiar, C F Toledo, Cla´áudia T. Carvente, MRa Souza, Borges, Mo^ônica R. A. Souza, Carlos Fischer de Toledo, JM Goto, Janaina M. Goto, Lak Aguiar, Claudia Teresa Carvente |
| المصدر: | Liver. 22:127-129 |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | HBsAg, medicine.medical_specialty, Cirrhosis, Hepatology, Vascular disease, business.industry, Helminthiasis, food and beverages, Schistosomiasis, medicine.disease, Gastroenterology, Internal medicine, Immunology, medicine, Portal hypertension, Complication, business, Thrombopoietin |
| الوصف: | Background: In severe forms of cirrhosis reduced liver synthesis of thrombopoietin (Tpo) can contribute to thrombocytopenia. In the hepatosplenic form of schistosomiasis, portal hypertension is the most evident clinical complication, although a deficiency of protein synthesis may be detected early. Our aim was to determine, for the first time in schistosomiasis, Tpo serum concentrations in patients with chronic forms of the disease. Method: Twenty-four patients with the pure form of schistosomiasis were studied; 13 had the hepatosplenic form (HE, with portal hypertension) and 11 had the hepatointestinal form (HI, without portal hypertension). Patients were HBsAg, anti-HBc and anti-HCV negative, and reported alcohol ingestion below 160 g/week. Results: The Tpo serum concentration, determined in 10 healthy volunteers, varied from undetectable ( 0.05). Conclusions: The results suggest that Tpo serum concentration does not mirror and/or has no significant participation in the mechanisms responsible for the thrombocytopenia observed in schistosomiasis patients with splenomegaly and portal hypertension. |
| تدمد: | 0106-9543 |
| DOI: | 10.1034/j.1600-0676.2002.01574.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e07d10c1e02cfe7f590a8b585cc5a17e https://doi.org/10.1034/j.1600-0676.2002.01574.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........e07d10c1e02cfe7f590a8b585cc5a17e |
| قاعدة البيانات: | OpenAIRE |
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